Literature DB >> 29675393

Autophagy: a potential target for the treatment of intraocular neovascularization.

Xia-Ru Zhu1, Jun-Hui Du1.   

Abstract

The formation of neovascularization is a common pathological feature of many ocular vascular diseases, and is an important cause of vision loss in patients. Neovascularization can cause retinal hemorrhage, vitreous hemorrhage, and other serious complications, leading to loss of vision. The treatment of intraocular neovascularization is the focus of ophthalmology research. In recent years, some studies have found that autophagy is closely related to vascular endothelial growth factor and the formation of neovascularization. Autophagy is expected to become a new target for the treatment of intraocular neovascularization. Therefore, this article reviews the research on autophagy and the formation of intraocular neovascularization.

Entities:  

Keywords:  angiogenesis; autophagy; vascular endothelial growth factor

Year:  2018        PMID: 29675393      PMCID: PMC5902379          DOI: 10.18240/ijo.2018.04.26

Source DB:  PubMed          Journal:  Int J Ophthalmol        ISSN: 2222-3959            Impact factor:   1.779


  31 in total

1.  Increased Serum Chemerin Levels in Diabetic Retinopathy of Type 2 Diabetic Patients.

Authors:  Junhui Du; Rong Li; Lin Xu; Ranran Ma; Jiali Liu; Jing Cheng; Zhong Zhang; Hongzhi Sun
Journal:  Curr Eye Res       Date:  2015-04-07       Impact factor: 2.424

2.  Autophagy control by the VEGF-C/NRP-2 axis in cancer and its implication for treatment resistance.

Authors:  Marissa J Stanton; Samikshan Dutta; Heyu Zhang; Navatha S Polavaram; Alexey A Leontovich; Pia Hönscheid; Frank A Sinicrope; Donald J Tindall; Michael H Muders; Kaustubh Datta
Journal:  Cancer Res       Date:  2012-11-13       Impact factor: 12.701

3.  Malondialdehyde induces autophagy dysfunction and VEGF secretion in the retinal pigment epithelium in age-related macular degeneration.

Authors:  Fuxiang Ye; Hiroki Kaneko; Yumi Hayashi; Kei Takayama; Shiang-Jyi Hwang; Yuji Nishizawa; Reona Kimoto; Yosuke Nagasaka; Taichi Tsunekawa; Toshiyuki Matsuura; Tsutomu Yasukawa; Takaaki Kondo; Hiroko Terasaki
Journal:  Free Radic Biol Med       Date:  2016-02-23       Impact factor: 7.376

Review 4.  Molecular analysis of blood vessel formation and disease.

Authors:  P Carmeliet; D Collen
Journal:  Am J Physiol       Date:  1997-11

Review 5.  Autophagy, a double-edged sword in anti-angiogenesis therapy.

Authors:  Jiatao Liu; Lulu Fan; Hua Wang; Guoping Sun
Journal:  Med Oncol       Date:  2015-12-29       Impact factor: 3.064

6.  Autophagy is involved in regulating VEGF during high-glucose-induced podocyte injury.

Authors:  Wei Miaomiao; Liu Chunhua; Zhang Xiaochen; Chen Xiaoniao; Lin Hongli; Yang Zhuo
Journal:  Mol Biosyst       Date:  2016-06-21

7.  HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

Authors:  Jung-whan Kim; Irina Tchernyshyov; Gregg L Semenza; Chi V Dang
Journal:  Cell Metab       Date:  2006-03       Impact factor: 27.287

8.  Autophagy and angiogenesis inhibition.

Authors:  Sundaram Ramakrishnan; Tri Minh Bui Nguyen; Indira V Subramanian; Ameeta Kelekar
Journal:  Autophagy       Date:  2007-07-13       Impact factor: 16.016

9.  Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.

Authors:  G L Semenza; B H Jiang; S W Leung; R Passantino; J P Concordet; P Maire; A Giallongo
Journal:  J Biol Chem       Date:  1996-12-20       Impact factor: 5.157

10.  Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy.

Authors:  Ji Liang; Yuji Piao; Verlene Henry; Ningyi Tiao; John F de Groot
Journal:  Oncotarget       Date:  2015-10-13
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  3 in total

1.  [Effects of icariin on autophagy and exosome production of bone microvascular endothelial cells].

Authors:  Qingyu Zhang; Fuqiang Gao; Liming Cheng; Lihua Liu; Wei Sun; Zirong Li
Journal:  Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi       Date:  2019-05-15

Review 2.  Autophagy in corneal health and disease: A concise review.

Authors:  Lynn M Martin; Nallathambi Jeyabalan; Ratnakar Tripathi; Trailokyanath Panigrahi; Philip J Johnson; Arkasubhra Ghosh; Rajiv R Mohan
Journal:  Ocul Surf       Date:  2019-01-25       Impact factor: 6.268

Review 3.  Autophagy in Extracellular Matrix and Wound Healing Modulation in the Cornea.

Authors:  Duraisamy Kempuraj; Rajiv R Mohan
Journal:  Biomedicines       Date:  2022-02-01
  3 in total

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