Lauren E Mak1, B Anne Croy2, Vanessa Kay2, James N Reynolds3, Matthew T Rätsep4, Nils D Forkert5, Graeme N Smith6, Angelina Paolozza7, Patrick W Stroman1, Ernesto A Figueiró-Filho8. 1. Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada. 2. Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. 3. Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. 4. Department of Obstetrics and Gynaecology, Queen's University, Kingston, ON, Canada. 5. Department of Radiology and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. 6. Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada; Department of Obstetrics and Gynaecology, Queen's University, Kingston, ON, Canada. 7. Laboratory for Infant Studies, University of Toronto Scarborough, Scarborough, ON, Canada. 8. Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada; Faculty of Medicine, Federal University of Mato Grosso do Sul, (FAMED-UFMS), Campo Grande, MS, Brazil. Electronic address: eaff@queensu.ca.
Abstract
BACKGROUND: Individuals (PE-F1s) born from preeclampsia (PE)-complicated pregnancies have elevated risks for cognitive impairment. Intervals of disturbed maternal plasma angiokines precede clinical signs of PE. We hypothesized pan-blastocyst dysregulation of angiokines underlies altered PE-F1 brain vascular and neurological development. This could alter brain functional connectivity (FC) patterns at rest. MATERIALS AND METHODS: Resting-state functional MRI datasets of ten, matched child pairs (5 boys and 5 girls aged 7-10 years of age) from PE or control pregnancies were available for study. Seed-based analysis and independent component analysis (ICA) methodologies were used to assess whether differences in resting-state functional connectivity (rs-FC) were present between PE-F1s and controls. Bilateral amygdala, bilateral hippocampus, and medial prefrontal cortex (MPFC) were selected as regions of interest (ROI) for the seed-based analysis based on previous imaging differences that we reported in this set of children. RESULTS: Compared to controls, PE-F1 children had increased rs-FC between the right amygdala and left frontal pole, the left amygdala and bilateral frontal pole, and the MPFC and precuneus. PE-F1 children additionally had decreased rs-FC between the MPFC and the left occipital fusiform gyrus compared to controls. CONCLUSION: These are the first reported rs-FC data for PE-F1s of any age. Theysuggest that PE alters FC during human fetal brain development. Altered FC may contribute to the behavioural and neurological alterations reported in PE-F1s. Longitudinal MRI studies with larger sample sizes are required to confirm these novel findings.
BACKGROUND: Individuals (PE-F1s) born from preeclampsia (PE)-complicated pregnancies have elevated risks for cognitive impairment. Intervals of disturbed maternal plasma angiokines precede clinical signs of PE. We hypothesized pan-blastocyst dysregulation of angiokines underlies altered PE-F1 brain vascular and neurological development. This could alter brain functional connectivity (FC) patterns at rest. MATERIALS AND METHODS: Resting-state functional MRI datasets of ten, matched child pairs (5 boys and 5 girls aged 7-10 years of age) from PE or control pregnancies were available for study. Seed-based analysis and independent component analysis (ICA) methodologies were used to assess whether differences in resting-state functional connectivity (rs-FC) were present between PE-F1s and controls. Bilateral amygdala, bilateral hippocampus, and medial prefrontal cortex (MPFC) were selected as regions of interest (ROI) for the seed-based analysis based on previous imaging differences that we reported in this set of children. RESULTS: Compared to controls, PE-F1children had increased rs-FC between the right amygdala and left frontal pole, the left amygdala and bilateral frontal pole, and the MPFC and precuneus. PE-F1children additionally had decreased rs-FC between the MPFC and the left occipital fusiform gyrus compared to controls. CONCLUSION: These are the first reported rs-FC data for PE-F1s of any age. Theysuggest that PE alters FC during human fetal brain development. Altered FC may contribute to the behavioural and neurological alterations reported in PE-F1s. Longitudinal MRI studies with larger sample sizes are required to confirm these novel findings.
Authors: Serena B Gumusoglu; Akanksha S S Chilukuri; Donna A Santillan; Mark K Santillan; Hanna E Stevens Journal: Trends Neurosci Date: 2020-03-06 Impact factor: 13.837
Authors: Serena Banu Gumusoglu; Akanksha Sri Satya Chilukuri; Benjamin Wen Qing Hing; Sabrina Marie Scroggins; Sreelekha Kundu; Jeremy Anton Sandgren; Mark Kharim Santillan; Donna Ann Santillan; Justin Lewis Grobe; Hanna Elizabeth Stevens Journal: Transl Psychiatry Date: 2021-01-28 Impact factor: 6.222