Nalin Abeydeera1, Inoka C Perera2, Theshini Perera1. 1. Department of Chemistry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka. 2. Department of Zoology and Environmental Science, University of Colombo, Colombo, Sri Lanka.
Abstract
Four Zn(II) complexes containing a pyridyl triazine core (L1 = 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5',5″-disulfonic acid disodium salt and L2 = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4',4″-disulfonic acid sodium salt) were synthesized, and their chemical formulas were finalized as [Zn(L1)Cl2]·5H2O·ZnCl2 (1), [Zn(L1)2Cl2]·4H2O·2CH3OH (2), [Zn(L2)Cl2]·3H2O·CH3OH (3), and [Zn(L2)2Cl2] (4). The synthesized complexes are water soluble, making them good candidates for biological applications. All four complexes have been characterized by elemental analysis and 1H NMR, IR, and UV-Vis spectroscopy. The IR stretching frequency of N=N and C=N bonds of complexes 1-4 have shifted to lower frequencies in comparison with free ligands, and a bathochromic shift was observed in UV-Vis spectra of all four complexes. The binding studies of ligands and complexes 1-4 with bovine serum albumin (BSA) resulted binding constants (Kb) of 3.09 × 104 M-1, 12.30 × 104 M-1, and 16.84 × 104 M-1 for ferene, complex 1, and complex 2, respectively, indicating potent serum distribution via albumins.
Four Zn(II) complexes containing a n class="Chemical">pyridyl triazine core (L1 = 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5',5″-disulfonic acid disodium salt and L2 = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4',4″-disulfonic acid sodium salt) were synthesized, and their chemical formulas were finalized as [Zn(L1)Cl2]·5H2O·ZnCl2 (1), [Zn(L1)2Cl2]·4H2O·2CH3OH (2), [Zn(L2)Cl2]·3H2O·CH3OH (3), and [Zn(L2)2Cl2] (4). The synthesized complexes are water soluble, making them good candidates for biological applications. All four complexes have been characterized by elemental analysis and 1H NMR, IR, and UV-Vis spectroscopy. The IR stretching frequency of N=N and C=N bonds of complexes 1-4 have shifted to lower frequencies in comparison with free ligands, and a bathochromic shift was observed in UV-Vis spectra of all four complexes. The binding studies of ligands and complexes 1-4 with bovineserum albumin (BSA) resulted binding constants (Kb) of 3.09 × 104 M-1, 12.30 × 104 M-1, and 16.84 × 104 M-1 for ferene, complex 1, and complex 2, respectively, indicating potent serum distribution via albumins.
Authors: Vidhi Maheshwari; Debadeep Bhattacharyya; Frank R Fronczek; Patricia A Marzilli; Luigi G Marzilli Journal: Inorg Chem Date: 2006-09-04 Impact factor: 5.165