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Literature DB >> 29670486

Utilizing Animal Models of Infantile Spasms.

Abstract

Infantile spasms are a devastating epileptic encephalopathy characterized by early life spasms and later seizures. Clinical outcomes of infantile spasms are poor and therapeutic options are limited with significant adverse effects. Therefore, new strategies to treat infantile spasms are of the utmost importance. Animals models of infantile spasms are a critical component of developing new therapies. Here, we review current chronic animal models of infantile spasms and consider future advances that may help improve patient care, as well as our scientific understanding of this debilitating disease.

Entities: Disease Species

Year: 2018 PMID： 29670486 PMCID： PMC5898247 DOI： 10.5698/1535-7597.18.2.107

Source DB: PubMed Journal: Epilepsy Curr ISSN： 1535-7511 Impact factor: 7.500

52 in total

1. A possible association of responsiveness to adrenocorticotropic hormone with specific GRIN1 haplotypes in infantile spasms.

Authors: Ying-Xue Ding; Ying Zhang; Bing He; Wei-Hua Yue; Dai Zhang; Li-Ping Zou
Journal: Dev Med Child Neurol Date: 2010-08-16 Impact factor: 5.449

Review 2. Genetic animal models of malformations of cortical development and epilepsy.

Authors: Michael Wong; Steven N Roper
Journal: J Neurosci Methods Date: 2015-04-21 Impact factor: 2.390

3. Infantile spasms is associated with deletion of the MAGI2 gene on chromosome 7q11.23-q21.11.

Authors: Christian R Marshall; Edwin J Young; Ariel M Pani; Mary-Louise Freckmann; Yves Lacassie; Cédric Howald; Kristi K Fitzgerald; Maarit Peippo; Colleen A Morris; Kate Shane; Manuela Priolo; Masafumi Morimoto; Ikuko Kondo; Esra Manguoglu; Sibel Berker-Karauzum; Patrick Edery; Holly H Hobart; Carolyn B Mervis; Orsetta Zuffardi; Alexandre Reymond; Paige Kaplan; May Tassabehji; Ronald G Gregg; Stephen W Scherer; Lucy R Osborne
Journal: Am J Hum Genet Date: 2008-06-19 Impact factor: 11.025

4. Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities.

Authors: J L Mohn; J Alexander; A Pirone; C D Palka; S-Y Lee; L Mebane; P G Haydon; M H Jacob
Journal: Mol Psychiatry Date: 2014-06-17 Impact factor: 15.992

5. Infantile spasms, dystonia, and other X-linked phenotypes caused by mutations in Aristaless related homeobox gene, ARX.

Authors: Petter Strømme; Marie E Mangelsdorf; Ingrid E Scheffer; Jozef Gécz
Journal: Brain Dev Date: 2002-08 Impact factor: 1.961

6. Expansion of the first PolyA tract of ARX causes infantile spasms and status dystonicus.

Authors: R Guerrini; F Moro; M Kato; A J Barkovich; T Shiihara; M A McShane; J Hurst; M Loi; J Tohyama; V Norci; K Hayasaka; U J Kang; S Das; W B Dobyns
Journal: Neurology Date: 2007-07-31 Impact factor: 9.910

7. A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment.

Authors: Maureen G Price; Jong W Yoo; Daniel L Burgess; Fang Deng; Richard A Hrachovy; James D Frost; Jeffrey L Noebels
Journal: J Neurosci Date: 2009-07-08 Impact factor: 6.167

8. Infantile spasms and Down syndrome: a new animal model.

Authors: Miguel A Cortez; Liqing Shen; Ying Wu; Ilyas S Aleem; Catherine H Trepanier; Hamid R Sadeghnia; Asim Ashraf; Ashlin Kanawaty; Chen-Chu Liu; Lee Stewart; O Carter Snead
Journal: Pediatr Res Date: 2009-05 Impact factor: 3.756

9. Loss of COUP-TFI alters the balance between caudal ganglionic eminence- and medial ganglionic eminence-derived cortical interneurons and results in resistance to epilepsy.

Authors: Simona Lodato; Giulio Srubek Tomassy; Elvira De Leonibus; Yoryani G Uzcategui; Gennaro Andolfi; Maria Armentano; Audrey Touzot; Jose M Gaztelu; Paola Arlotta; Liset Menendez de la Prida; Michèle Studer
Journal: J Neurosci Date: 2011-03-23 Impact factor: 6.167

10. Hyper-excitability and epilepsy generated by chronic early-life stress.

Authors: Céline M Dubé; Jenny Molet; Akanksha Singh-Taylor; Autumn Ivy; Pamela M Maras; Tallie Z Baram
Journal: Neurobiol Stress Date: 2015

8 in total

1. Acthar® Gel (repository corticotropin injection) dose-response relationships in an animal model of epileptic spasms.

Authors: John T Le; James D Frost; John W Swann
Journal: Epilepsy Behav Date: 2021-02-03 Impact factor: 3.337

2. Aged heterozygous Cdkl5 mutant mice exhibit spontaneous epileptic spasms.

Authors: Patrick J Mulcahey; Sheng Tang; Hajime Takano; Alicia White; Dayana R Davila Portillo; Owen M Kane; Eric D Marsh; Zhaolan Zhou; Douglas A Coulter
Journal: Exp Neurol Date: 2020-06-22 Impact factor: 5.620

3. Early developmental electroencephalography abnormalities, neonatal seizures, and induced spasms in a mouse model of tuberous sclerosis complex.

Authors: Nicholas Rensing; Kevin J Johnson; Thomas J Foutz; Joseph L Friedman; Rafael Galindo; Michael Wong
Journal: Epilepsia Date: 2020-04-10 Impact factor: 6.740

4. mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus.

Authors: Tomas Petrasek; Iveta Vojtechova; Ondrej Klovrza; Klara Tuckova; Cestmir Vejmola; Jakub Rak; Anna Sulakova; Daniel Kaping; Nadine Bernhardt; Petrus J de Vries; Jakub Otahal; Robert Waltereit
Journal: J Neurodev Disord Date: 2021-04-17 Impact factor: 4.025