Yuanyuan Cui1, Huiyu Qiao2, Lu Ma1, Mingming Lu1, Jiafei Yang3, Guoen Yao4, Jianming Cai1,3, Xihai Zhao2. 1. Department of Radiology, PLA General Hospital. 2. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine. 3. Department of Radiology, First Affiliated Hospital of PLA General Hospital. 4. Department of Neurology, First Affiliated Hospital of PLA General Hospital.
Abstract
AIM: To investigate the association between the volumes of different aging intraplaque hemorrhage (IPH) and minor fibrous cap disruption (MFCD) in carotid arteries. METHODS: Patients with cerebrovascular symptoms and carotid atherosclerotic plaques determined by ultrasound were recruited and underwent multi-contrast magnetic resonance (MR) vessel wall imaging for carotid arteries. Carotid plaques with IPH on MR imaging were included in the analysis. The age (fresh or recent) and the volume of IPH for each plaque were evaluated. RESULTS: In total, 41 carotid plaques in 37 patients (mean age 70.2±11.0 years old; 32 males) were eligible for statistical analysis. The absolute volume of fresh IPH in plaques with MFCD was significantly larger than that in plaques without MFCD (109.83±75.49 mm3 vs. 30.54±20.62 mm3, P=0.002). Logistic regression showed that the absolute volume of fresh IPH was significantly associated with MFCD before (odds ratio [OR], 1.735; 95% confidence interval [CI], 1.127-2.670; P=0.012) and after adjusting for confounding factors (OR, 1.823; 95% CI, 1.076-3.090; P=0.026). There was no significant association between recent IPH volume and MFCD (P＞0.05). CONCLUSION: The volume of fresh IPH is independently associated with MFCD in carotid plaques, suggesting that integrity of fibrous cap may change with different age and size of IPH.
AIM: To investigate the association between the volumes of different aging intraplaque hemorrhage (IPH) and minor fibrous cap disruption (MFCD) in carotid arteries. METHODS:Patients with cerebrovascular symptoms and carotid atherosclerotic plaques determined by ultrasound were recruited and underwent multi-contrast magnetic resonance (MR) vessel wall imaging for carotid arteries. Carotid plaques with IPH on MR imaging were included in the analysis. The age (fresh or recent) and the volume of IPH for each plaque were evaluated. RESULTS: In total, 41 carotid plaques in 37 patients (mean age 70.2±11.0 years old; 32 males) were eligible for statistical analysis. The absolute volume of fresh IPH in plaques with MFCD was significantly larger than that in plaques without MFCD (109.83±75.49 mm3 vs. 30.54±20.62 mm3, P=0.002). Logistic regression showed that the absolute volume of fresh IPH was significantly associated with MFCD before (odds ratio [OR], 1.735; 95% confidence interval [CI], 1.127-2.670; P=0.012) and after adjusting for confounding factors (OR, 1.823; 95% CI, 1.076-3.090; P=0.026). There was no significant association between recent IPH volume and MFCD (P＞0.05). CONCLUSION: The volume of fresh IPH is independently associated with MFCD in carotid plaques, suggesting that integrity of fibrous cap may change with different age and size of IPH.
Entities:
Keywords:
Atherosclerosis; Cardiovascular diseases; Carotid artery; Magnetic resonance imaging; Stenosis
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