| Literature DB >> 29669294 |
Wenfei Zhu1, Jie Dong1, Ye Zhang1, Lei Yang1, Xiyan Li1, Tao Chen1, Xiang Zhao1, Hejiang Wei1, Hong Bo1, Xiaoxu Zeng1, Weijuan Huang1, Zi Li1, Jing Tang1, Jianfang Zhou1, Rongbao Gao1, Li Xin1, Jing Yang1, Shumei Zou1, Wenbing Chen1, Jia Liu1, Yuelong Shu2, Dayan Wang3.
Abstract
The 2016-2017 epidemic of influenza A (H7N9) virus in China prompted concern that a genetic change may underlie increased virulence. Based on an evolutionary analysis of H7N9 viruses from all five outbreak waves, we find that additional subclades of the H7 and N9 genes have emerged. Our analysis indicates that H7N9 viruses inherited NP genes from co-circulating H7N9 instead of H9N2 viruses. Genotypic diversity among H7N9 viruses increased following wave I, peaked during wave III, and rapidly deceased thereafter with minimal diversity in wave V, suggesting that the viruses entered a relatively stable evolutionary stage. The ZJ11 genotype caused the majority of human infections in wave V. We suggest that the largest outbreak of wave V may be due to a constellation of genes rather than a single mutation. Therefore, continuous surveillance is necessary to minimize the threat of H7N9 viruses.Entities:
Keywords: NP gene; PB2 A588V; gene constellation; influenza A (H7N9) viruses; the fifth wave
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Year: 2018 PMID： 29669294 DOI： 10.1016/j.celrep.2018.03.081
Source DB: PubMed Journal: Cell Rep Impact factor: 9.423