| Literature DB >> 2966886 |
V L Dawson1, T M Dawson, F M Filloux, J K Wamsley.
Abstract
The aziridinium ion of ethylcholine (AF64A) is a neurotoxin that has demonstrated selectivity for cholinergic neurons. Unilateral stereotaxic injection of AF64A into the caudate-putamen of rats, resulted in a decrease in dopamine D-2 receptors as evidenced by a decrease in [3H]-sulpiride binding. Dopamine D-1 receptors, labeled with [3H]-SCH 23390, were unchanged. The efficacy of the lesion was demonstrated by the reduction of Na+-dependent high affinity choline uptake sites labeled with [3H]-hemicholinium-3. These data indicate that a population of D-2 receptors are postsynaptic on cholinergic interneurons within the striatum of rat brain.Entities:
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Year: 1988 PMID： 2966886 DOI： 10.1016/0024-3205(88)90492-4
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037