Literature DB >> 29667928

Skin cells prefer a slower calcium pump.

Seth L Robia1, Howard S Young2.   

Abstract

Naturally occurring mutations of a calcium ion transporter can cause a skin condition known as Darier's disease. In this issue of JBC, Mikkelsen et al. describe a particularly interesting Darier's mutation that alters calcium transport by disrupting a kinetic braking mechanism that is unique to the SERCA2b calcium pump isoform. The study provides new insight into the intrinsic regulation of this transporter and reveals how disruption of regulation can lead to disease in Darier's patients.
© 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

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Year:  2018        PMID： 29667928      PMCID： PMC5857981          DOI： 10.1074/jbc.H118.002088

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  6 in total

1.  Transmembrane helix 11 is a genuine regulator of the endoplasmic reticulum Ca2+ pump and acts as a functional parallel of β-subunit on α-Na+,K+-ATPase.

Authors:  Przemek A Gorski; Catharine A Trieber; Els Larivière; Marleen Schuermans; Frank Wuytack; Howard S Young; Peter Vangheluwe
Journal:  J Biol Chem       Date:  2012-04-23       Impact factor: 5.157

2.  A Darier disease mutation relieves kinetic constraints imposed by the tail of sarco(endo)plasmic reticulum Ca2+-ATPase 2b.

Authors:  Stine A Mikkelsen; Peter Vangheluwe; Jens Peter Andersen
Journal:  J Biol Chem       Date:  2018-01-23       Impact factor: 5.157

Review 3.  The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus.

Authors:  Ilse Vandecaetsbeek; Peter Vangheluwe; Luc Raeymaekers; Frank Wuytack; Jo Vanoevelen
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-05-01       Impact factor: 10.005

4.  Distinct roles of the C-terminal 11th transmembrane helix and luminal extension in the partial reactions determining the high Ca2+ affinity of sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2b (SERCA2b).

Authors:  Johannes D Clausen; Ilse Vandecaetsbeek; Frank Wuytack; Peter Vangheluwe; Jens Peter Andersen
Journal:  J Biol Chem       Date:  2012-09-28       Impact factor: 5.157

5.  Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease.

Authors:  A Sakuntabhai; V Ruiz-Perez; S Carter; N Jacobsen; S Burge; S Monk; M Smith; C S Munro; M O'Donovan; N Craddock; R Kucherlapati; J L Rees; M Owen; G M Lathrop; A P Monaco; T Strachan; A Hovnanian
Journal:  Nat Genet       Date:  1999-03       Impact factor: 38.330

6.  Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump.

Authors:  Ilse Vandecaetsbeek; Mieke Trekels; Marc De Maeyer; Hugo Ceulemans; Eveline Lescrinier; Luc Raeymaekers; Frank Wuytack; Peter Vangheluwe
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-21       Impact factor: 11.205
  6 in total
  1 in total

1.  Spiny mice (Acomys) exhibit attenuated hallmarks of aging and rapid cell turnover after UV exposure in the skin epidermis.

Authors:  Wesley Wong; Austin Kim; James R Monaghan; Ashley W Seifert; Malcolm Maden; Justin D Crane
Journal:  PLoS One       Date:  2020-10-30       Impact factor: 3.240
  1 in total

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