G Grani1, L Lamartina1, T Montesano2, G Ronga2, V Maggisano3, R Falcone1, V Ramundo1, L Giacomelli4, C Durante5, D Russo3, M Maranghi1. 1. Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico, 155, 00161, Rome, RM, Italy. 2. Unità di Medicina Nucleare, Sapienza Università di Roma, Rome, Italy. 3. Dipartimento di Scienze della Salute, Università di Catanzaro "Magna Graecia", Catanzaro, Italy. 4. Dipartimento di Scienze Chirurgiche, Sapienza Università di Roma, Rome, Italy. 5. Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico, 155, 00161, Rome, RM, Italy. cosimo.durante@uniroma1.it.
Abstract
PURPOSE: Aim of this study was to evaluate the association between body mass index (BMI) and aggressive features of differentiated thyroid cancer (DTC) in a prospective cohort. METHODS: Patients with DTC were prospectively enrolled at a tertiary referral center and grouped according to their BMI. Aggressive clinic-pathological features were analyzed following the American Thyroid Association Initial Risk Stratification System score. RESULTS: The cohort was composed of 432 patients: 5 (1.2%) were underweight, 187 (43.3%) normal weight, 154 (35.6%) overweight, 68 (15.7%) grade 1 obese, 11 (2.5%) grade 2 obese and 7 (1.6%) grade 3 obese. No single feature of advanced thyroid cancer was more frequent in obese patients than in others. No significant correlation was found between BMI, primary tumor size (Spearman's ρ - 0.02; p = 0.71) and ATA Initial Risk Stratification System score (ρ 0.03; p = 0.49), after adjustment for age. According to the multivariate logistic regression analysis, male gender and pre-surgical diagnosis of cancer were significant predictors of cancer with high or intermediate-high recurrence risk according to the ATA system (OR 2.06 and 2.51, respectively), while older age at diagnosis was a protective factor (OR 0.98), and BMI was not a predictor. BMI was a predictor of microscopic extrathyroidal extension only (OR 1.06). CONCLUSIONS: Obesity was not associated with aggressive features in this prospective, European cohort of patients with DTC.
PURPOSE: Aim of this study was to evaluate the association between body mass index (BMI) and aggressive features of differentiated thyroid cancer (DTC) in a prospective cohort. METHODS:Patients with DTC were prospectively enrolled at a tertiary referral center and grouped according to their BMI. Aggressive clinic-pathological features were analyzed following the American Thyroid Association Initial Risk Stratification System score. RESULTS: The cohort was composed of 432 patients: 5 (1.2%) were underweight, 187 (43.3%) normal weight, 154 (35.6%) overweight, 68 (15.7%) grade 1 obese, 11 (2.5%) grade 2 obese and 7 (1.6%) grade 3 obese. No single feature of advanced thyroid cancer was more frequent in obesepatients than in others. No significant correlation was found between BMI, primary tumor size (Spearman's ρ - 0.02; p = 0.71) and ATA Initial Risk Stratification System score (ρ 0.03; p = 0.49), after adjustment for age. According to the multivariate logistic regression analysis, male gender and pre-surgical diagnosis of cancer were significant predictors of cancer with high or intermediate-high recurrence risk according to the ATA system (OR 2.06 and 2.51, respectively), while older age at diagnosis was a protective factor (OR 0.98), and BMI was not a predictor. BMI was a predictor of microscopic extrathyroidal extension only (OR 1.06). CONCLUSIONS:Obesity was not associated with aggressive features in this prospective, European cohort of patients with DTC.
Entities:
Keywords:
Advanced stage; Aggressive cancer; Body mass index; Cancer size; Obesity; Thyroid cancer
Authors: Danuta Gąsior-Perczak; Iwona Pałyga; Monika Szymonek; Artur Kowalik; Agnieszka Walczyk; Janusz Kopczyński; Katarzyna Lizis-Kolus; Tomasz Trybek; Estera Mikina; Dorota Szyska-Skrobot; Klaudia Gadawska-Juszczyk; Stefan Hurej; Artur Szczodry; Anna Słuszniak; Janusz Słuszniak; Ryszard Mężyk; Stanisław Góźdź; Aldona Kowalska Journal: PLoS One Date: 2018-10-01 Impact factor: 3.240