Young Wook Chun1, Matthew D Durbin2, Charles C Hong3. 1. Departments of Medicine - Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, PRB 383, Nashville, TN, 37232, USA. 2. Department of Pediatrics - Division of Neonatal-Perinatal Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. 3. Departments of Medicine - Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, PRB 383, Nashville, TN, 37232, USA. charles.c.hong@vanderbilt.edu.
Abstract
PURPOSE OF REVIEW: The goal of this review is to highlight the potential of induced pluripotent stem cell (iPSC)-based modeling as a tool for studying human cardiovascular diseases. We present some of the current cardiovascular disease models utilizing genome editing and patient-derived iPSCs. RECENT FINDINGS: The incorporation of genome-editing and iPSC technologies provides an innovative research platform, providing novel insight into human cardiovascular disease at molecular, cellular, and functional level. In addition, genome editing in diseased iPSC lines holds potential for personalized regenerative therapies. The study of human cardiovascular disease has been revolutionized by cellular reprogramming and genome editing discoveries. These exceptional technologies provide an opportunity to generate human cell cardiovascular disease models and enable therapeutic strategy development in a dish. We anticipate these technologies to improve our understanding of cardiovascular disease pathophysiology leading to optimal treatment for heart diseases in the future.
PURPOSE OF REVIEW: The goal of this review is to highlight the potential of induced pluripotent stem cell (iPSC)-based modeling as a tool for studying humancardiovascular diseases. We present some of the current cardiovascular disease models utilizing genome editing and patient-derived iPSCs. RECENT FINDINGS: The incorporation of genome-editing and iPSC technologies provides an innovative research platform, providing novel insight into humancardiovascular disease at molecular, cellular, and functional level. In addition, genome editing in diseased iPSC lines holds potential for personalized regenerative therapies. The study of humancardiovascular disease has been revolutionized by cellular reprogramming and genome editing discoveries. These exceptional technologies provide an opportunity to generate human cell cardiovascular disease models and enable therapeutic strategy development in a dish. We anticipate these technologies to improve our understanding of cardiovascular disease pathophysiology leading to optimal treatment for heart diseases in the future.
Authors: Fyodor D Urnov; Jeffrey C Miller; Ya-Li Lee; Christian M Beausejour; Jeremy M Rock; Sheldon Augustus; Andrew C Jamieson; Matthew H Porteus; Philip D Gregory; Michael C Holmes Journal: Nature Date: 2005-04-03 Impact factor: 49.962
Authors: Ning Sun; Masayuki Yazawa; Jianwei Liu; Leng Han; Veronica Sanchez-Freire; Oscar J Abilez; Enrique G Navarrete; Shijun Hu; Li Wang; Andrew Lee; Aleksandra Pavlovic; Shin Lin; Rui Chen; Roger J Hajjar; Michael P Snyder; Ricardo E Dolmetsch; Manish J Butte; Euan A Ashley; Michael T Longaker; Robert C Robbins; Joseph C Wu Journal: Sci Transl Med Date: 2012-04-18 Impact factor: 17.956
Authors: Young Wook Chun; Daniel A Balikov; Tromondae K Feaster; Charles H Williams; Calvin C Sheng; Jung-Bok Lee; Timothy C Boire; M Diana Neely; Leon M Bellan; Kevin C Ess; Aaron B Bowman; Hak-Joon Sung; Charles C Hong Journal: Biomaterials Date: 2015-07-14 Impact factor: 12.479
Authors: Kazuki Kodo; Sang-Ging Ong; Fereshteh Jahanbani; Vittavat Termglinchan; Keiichi Hirono; Kolsoum InanlooRahatloo; Antje D Ebert; Praveen Shukla; Oscar J Abilez; Jared M Churko; Ioannis Karakikes; Gwanghyun Jung; Fukiko Ichida; Sean M Wu; Michael P Snyder; Daniel Bernstein; Joseph C Wu Journal: Nat Cell Biol Date: 2016-09-19 Impact factor: 28.824
Authors: Sandrine Boissel; Jordan Jarjour; Alexander Astrakhan; Andrew Adey; Agnès Gouble; Philippe Duchateau; Jay Shendure; Barry L Stoddard; Michael T Certo; David Baker; Andrew M Scharenberg Journal: Nucleic Acids Res Date: 2013-11-26 Impact factor: 16.971