Muhammad Nazmuddin1, D L Marinus Oterdoom2, J Marc C van Dijk2, Jonathan C van Zijl1, Anne K Kampman2, Gea Drost2, Teus van Laar1, Martijn Beudel3. 1. Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands. 2. Department of Neurosurgery, University Medical Center Groningen, Groningen, The Netherlands. 3. Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands; Department of Neurology, Isala Klinieken, Zwolle, The Netherlands. Electronic address: M.Beudel@umcg.nl.
Abstract
BACKGROUND: Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is a new potential treatment for Parkinson's Disease dementia (PDD) and other types of dementia. To get a better understanding of this structure, its local neurophysiological properties and cortical connectivity patterns were studied. METHODS: We simultaneously recorded DBS local field potentials (LFPs) and electroencephalography (EEG) in two patients with PDD. Both patients had DBS electrodes in the internal globus pallidus (GPi) with one or more distal contacts close to or inside the NBM. Measurements were obtained during routine battery replacement. The distance of DBS contacts to the NBM were calculated using CT-MRI fusion. RESULTS: Delta (1-4 Hz) oscillations were more prominently present in the NBM region than in its vicinity, whereas temporal coherence in the theta (4-8 Hz) range was less outspoken. CONCLUSION: These neurophysiological characteristics, if also proven in larger cohorts, might help to map the NBM more precisely during electrode implantation.
BACKGROUND: Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is a new potential treatment for Parkinson's Disease dementia (PDD) and other types of dementia. To get a better understanding of this structure, its local neurophysiological properties and cortical connectivity patterns were studied. METHODS: We simultaneously recorded DBS local field potentials (LFPs) and electroencephalography (EEG) in two patients with PDD. Both patients had DBS electrodes in the internal globus pallidus (GPi) with one or more distal contacts close to or inside the NBM. Measurements were obtained during routine battery replacement. The distance of DBS contacts to the NBM were calculated using CT-MRI fusion. RESULTS:Delta (1-4 Hz) oscillations were more prominently present in the NBM region than in its vicinity, whereas temporal coherence in the theta (4-8 Hz) range was less outspoken. CONCLUSION: These neurophysiological characteristics, if also proven in larger cohorts, might help to map the NBM more precisely during electrode implantation.
Authors: Shenghong He; Alceste Deli; Petra Fischer; Christoph Wiest; Yongzhi Huang; Sean Martin; Saed Khawaldeh; Tipu Z Aziz; Alexander L Green; Peter Brown; Huiling Tan Journal: J Neurosci Date: 2021-08-19 Impact factor: 6.167
Authors: I Daria Bogdan; D L Marinus Oterdoom; Teus van Laar; Rients B Huitema; Vincent J Odekerken; Judith A Boel; Rob M A de Bie; J Marc C van Dijk Journal: J Clin Med Date: 2022-01-11 Impact factor: 4.241