| Literature DB >> 29665786 |
Lee-Hwa Tai1, Abhirami A Ananth1,2, Rashmi Seth3, Almohanad Alkayyal1,2,4, Jiqing Zhang2,5,6, Christiano Tanese de Souza2, Phillip Staibano2, Michael A Kennedy2, Rebecca C Auer7,8,9,10.
Abstract
It has been highlighted that the original manuscript [1] contains a typesetting error in Fig. 1 and the Fig. 1c panel gas been inadvertently duplicated in panel Fig. 1d. This does not affect the results and conclusions of the article. The correct version of Fig. 1 is included with this Correction. The original article has been updated.Entities:
Year: 2018 PMID: 29665786 PMCID: PMC5905137 DOI: 10.1186/s12885-018-4248-2
Source DB: PubMed Journal: BMC Cancer ISSN: 1471-2407 Impact factor: 4.430
Fig. 1Hemorrhagic shock does not increase metastatic disease. a Experimental overview. BALB/c mice were bled through the saphenous vein (indicated by the white arrow) and subsequently injected intravenously (IV) through the tail vein with 3 × 105 CT26LacZ cells. Approximately 1 h later, surgical stress (sx) was generated by laparotomy (Lap) (5 cm incision). Mice were sacrificed at 72 h to quantify lung metastases. b Blood pressure is reduced following surgical stress and blood loss. Blood pressure (mmHg) was measured following a 5-day training period (Day 1–5), prior to bleeding (Pre), immediately following bleeding (Post-BL), and immediately following surgical stress (Post-Sx and BL, n = 3). c Blood loss increases metastatic burden. Lung metastases were measured on Day 3 following no blood loss (no BL, n = 3) or 20% (20% BL, n = 3) or 30% blood loss (30% BL, n = 4). d Blood loss does not increase metastatic disease in conjunction with surgical stress. Lung metastases were measure on Day 3 in mice that did not undergo surgical stress (No Sx, n = 5) and animals undergoing a laparotomy (Lap, n = 4) alone or in combination with 30% blood loss (Lap + 30% BL, n = 5). Error bars represent ± SEM