PURPOSE: Synovial membrane inflammation is the most commonly presenting finding during hip arthroscopy and may have a role in the pathomechanism of hip osteoarthritis (OA). The aim of this study was to determine the relationship between synovial cytokine levels and progression of OA after hip arthroscopy. METHODS: We prospectively examined 20 patients (20 hips) who underwent arthroscopic hip surgery. For all patients, radiographs and severity of pain were evaluated preoperatively. During arthroscopy, we harvested a sample of the synovial membrane and determined the levels of six typical inflammatory cytokines with real-time polymerase chain reaction. We compared the levels of these cytokines in patients who showed OA progression and non-progression after hip arthroscopy. RESULTS: Although the average age of patients who showed OA progression postoperatively tended to be higher, there were no significant differences in characteristics involving clinical assessment between patients who showed OA progression and those who showed non-progression. Intraoperative tumour necrosis factor α (TNFα) expression was significantly higher in patients who showed OA progression postoperatively ( p = 0.042). CONCLUSIONS: Elevation of TNFα level might be a predictor of OA progression after hip arthroscopy.
PURPOSE: Synovial membrane inflammation is the most commonly presenting finding during hip arthroscopy and may have a role in the pathomechanism of hip osteoarthritis (OA). The aim of this study was to determine the relationship between synovial cytokine levels and progression of OA after hip arthroscopy. METHODS: We prospectively examined 20 patients (20 hips) who underwent arthroscopic hip surgery. For all patients, radiographs and severity of pain were evaluated preoperatively. During arthroscopy, we harvested a sample of the synovial membrane and determined the levels of six typical inflammatory cytokines with real-time polymerase chain reaction. We compared the levels of these cytokines in patients who showed OA progression and non-progression after hip arthroscopy. RESULTS: Although the average age of patients who showed OA progression postoperatively tended to be higher, there were no significant differences in characteristics involving clinical assessment between patients who showed OA progression and those who showed non-progression. Intraoperative tumour necrosis factor α (TNFα) expression was significantly higher in patients who showed OA progression postoperatively ( p = 0.042). CONCLUSIONS: Elevation of TNFα level might be a predictor of OA progression after hip arthroscopy.
Entities:
Keywords:
cytokine; femoroacetabular impingement; hip arthroscopy; hip osteoarthritis; synovial membrane inflammation
Authors: C H Teirlinck; D M J Dorleijn; P K Bos; J B M Rijkels-Otters; S M A Bierma-Zeinstra; P A J Luijsterburg Journal: Arthritis Res Ther Date: 2019-08-23 Impact factor: 5.156
Authors: Van Thi Nguyen; Barbara Canciani; Federica Cirillo; Luigi Anastasia; Giuseppe M Peretti; Laura Mangiavini Journal: Cells Date: 2020-03-19 Impact factor: 6.600
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