Yong Wang1,2, Sangsang Li1, Chunjing Chen1, Qizhi Luo1, Yu Li3, Limin Liu4, Xiaoling Fu5, Ping Yu1, Fuyan Wang1. 1. Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China. 2. Department of Forensic Science, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China. 3. Department of Basic Medicine and Clinical Laboratory, Yiyang Medical College, Yiyang, Hunan, China. 4. Liuzhou Worker's Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China. 5. Department of Blood Transfusion, Hainan General Hospital, Haikou, Hainan, China.
Abstract
AIM: Rheumatoid arthritis (RA) as an inflammatory autoimmune disease affects the synovial joints as well as other organs and tissues. Since aberrant expression of MIC molecules has been observed in RA patient, MIC genotypes might play certain roles in the development of RA. METHOD: To explore the association of MICA and MICB polymorphisms with RA in a Han Chinese population in Hainan Island, samples from 172 RA and 137 healthy controls were genotyped for MICA and MICB. RESULTS: Our results indicated that MICB*002 and MICB*014 were less frequent in RA patients than in controls (P = 0.000, 0.005) while there were higher percentages of RA patients carrying MICA*009 and MICA*A6 (P = 0.005). CONCLUSION: Different MIC variants might modulate the autoimmune reaction differently in RA disease and therefore serve as protective or risk factors.
AIM: Rheumatoid arthritis (RA) as an inflammatory autoimmune disease affects the synovial joints as well as other organs and tissues. Since aberrant expression of MIC molecules has been observed in RApatient, MIC genotypes might play certain roles in the development of RA. METHOD: To explore the association of MICA and MICB polymorphisms with RA in a Han Chinese population in Hainan Island, samples from 172 RA and 137 healthy controls were genotyped for MICA and MICB. RESULTS: Our results indicated that MICB*002 and MICB*014 were less frequent in RApatients than in controls (P = 0.000, 0.005) while there were higher percentages of RApatients carrying MICA*009 and MICA*A6 (P = 0.005). CONCLUSION: Different MIC variants might modulate the autoimmune reaction differently in RA disease and therefore serve as protective or risk factors.
Authors: Panpimon Luangtrakool; Sasijit Vejbaesya; Komon Luangtrakool; Somporn Ngamhawornwong; Kusuma Apisawes; Siripen Kalayanarooj; Louis R Macareo; Stefan Fernandez; Richard G Jarman; Robert W M Collins; Steven T Cox; Anon Srikiatkhachorn; Alan L Rothman; Henry A F Stephens Journal: J Infect Dis Date: 2020-08-04 Impact factor: 5.226
Authors: Karen Toledo-Stuardo; Carolina H Ribeiro; Andrea Canals; Marcela Morales; Valentina Gárate; Jose Rodríguez-Siza; Samantha Tello; Marco Bustamante; Ricardo Armisen; Douglas J Matthies; Gerald Zapata-Torres; Patricio González-Hormazabal; María Carmen Molina Journal: Front Immunol Date: 2021-03-31 Impact factor: 7.561