Caroline Sampaio Nunes1, Michael Maes2,3,4,5, Chutima Roomruangwong3, Juliana Brum Moraes2, Kamila Landucci Bonifacio1, Heber Odebrecht Vargas1,2,6, Decio Sabbatini Barbosa2, George Anderson7, Luiz Gustavo Piccoli de Melo1,2, Stoyanov Drozdstoj4, Estefania Moreira2, André F Carvalho8,9, Sandra Odebrecht Vargas Nunes1,2. 1. Department of Psychiatry, Health Sciences Center, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil. 2. Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil. 3. Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. 4. Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria. 5. IMPACT Strategic Research Centre, Deakin University, Geelong, VIC, Australia. 6. Center for Approach and Treatment for Smokers, University Hospital, State University of Londrina, Londrina, Paraná, Brazil. 7. Clinical Research Center Scotland & London, London, UK. 8. Department of Psychiatry, University of Toronto, Toronto, ON, Canada. 9. Centre for Addiction & Mental Health, Toronto, ON, Canada.
Abstract
RATIONALE, AIMS: Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD. METHODS: This cross-sectional study enrolled 68 BD and 37 MDD patients and 66 healthy controls. The World Health Organization (WHO) QoL-BREF scale was used to assess 4 QoL subdomains. Peripheral blood malondialdehyde (MDA), advanced oxidation protein products, paraoxonaxe/CMPAase activity, a composite index of nitro-oxidative stress, and basal TSH were measured. RESULTS: In the total WHOQoL score, 17.3% of the variance was explained by increased advanced oxidation protein products and TSH levels and lowered CMPAase activity and male gender. Physical HRQoL (14.4%) was associated with increased MDA and TSH levels and lowered CMPAase activity. Social relations HRQoL (17.4%) was predicted by higher nitro-oxidative index and TSH values, while mental and environment HRQoL were independently predicted by CMPAase activity. Finally, 73.0% of the variance in total HRQoL was explained by severity of depressive symptoms, use of anticonvulsants, lower income, early lifetime emotional neglect, MDA levels, the presence of mood disorders, and suicidal ideation. CONCLUSIONS: These data show that lowered HRQoL in major affective disorders could at least in part result from the effects of lipid peroxidation, protein oxidation, lowered antioxidant enzyme activities, and higher levels of TSH.
RATIONALE, AIMS: Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD. METHODS: This cross-sectional study enrolled 68 BD and 37 MDDpatients and 66 healthy controls. The World Health Organization (WHO) QoL-BREF scale was used to assess 4 QoL subdomains. Peripheral blood malondialdehyde (MDA), advanced oxidation protein products, paraoxonaxe/CMPAase activity, a composite index of nitro-oxidative stress, and basal TSH were measured. RESULTS: In the total WHOQoL score, 17.3% of the variance was explained by increased advanced oxidation protein products and TSH levels and lowered CMPAase activity and male gender. Physical HRQoL (14.4%) was associated with increased MDA and TSH levels and lowered CMPAase activity. Social relations HRQoL (17.4%) was predicted by higher nitro-oxidative index and TSH values, while mental and environment HRQoL were independently predicted by CMPAase activity. Finally, 73.0% of the variance in total HRQoL was explained by severity of depressive symptoms, use of anticonvulsants, lower income, early lifetime emotional neglect, MDA levels, the presence of mood disorders, and suicidal ideation. CONCLUSIONS: These data show that lowered HRQoL in major affective disorders could at least in part result from the effects of lipid peroxidation, protein oxidation, lowered antioxidant enzyme activities, and higher levels of TSH.
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Authors: Michael Maes; Haneen Tahseen Al-Rubaye; Abbas F Almulla; Dhurgham Shihab Al-Hadrawi; Kristina Stoyanova; Marta Kubera; Hussein Kadhem Al-Hakeim Journal: Int J Environ Res Public Health Date: 2022-08-19 Impact factor: 4.614
Authors: Michael Maes; Thitiporn Supasitthumrong; Chusak Limotai; Ana Paula Michelin; Andressa Keiko Matsumoto; Laura de Oliveira Semão; João Victor de Lima Pedrão; Estefânia Gastaldello Moreira; Andre F Carvalho; Sunee Sirivichayakul; Décio Sabbatini Barbosa; Buranee Kanchanatawan Journal: Mol Neurobiol Date: 2020-06-09 Impact factor: 5.682