Hitesh Shah1, Benjamin Joseph2, Binu V S Nair3, Devaki B Kotian3, In Ho Choi4, Benjamin Stephens Richards5, Charles Johnston6, Vrisha Madhuri7, Matthew B Dobbs8, Mark Dahl9. 1. Paediatric Orthopaedic Service, Kasturba Medical College. 2. Aster Medcity, Kuttisahib Road, South Chittoor, Kochi, Kerala. 3. Department of Statistics, Prasanna School of Public Health, Manipal University, Manipal, Karnataka. 4. Division of Pediatric Orthopaedics, Seoul National University Children's Hospital, Seoul, Republic of Korea. 5. Department of Orthopaedic Surgery, University Texas, Southwestern Medical Center and Texas Scottish Rite Hospital for Children. 6. Department of Orthopedic Surgery, University of Texas, Southwestern Medical School and Texas Scottish Rite Hospital for Children, Dallas, TX. 7. Paediatric Orthopaedic Unit, Christian Medical College and Hospital, Vellore, Tamilnadu, India. 8. Washington University School of Medicine, Saint Louis, MO. 9. Limb Length and Deformity Correction, Gillette Children's Specialty Healthcare, St. Paul, MN.
Abstract
OBJECTIVE: To identify factors influencing union of congenital pseudarthrosis of the tibia (CPT), refractures, and integrity of the tibia at maturity. METHODS: Data of 119 children operated for Crawford-type IV CPT and followed-up till skeletal maturity were analyzed. Logistic regression and recursive partitioning analyses were used to test associations between several variables and the outcome. RESULTS: Primary union occurred in 86% of children. At maturity, 69% remained soundly united. The odds ratio for failure of primary union was 3.89 (95% confidence interval, 1.05-14.40; P=0.042) when bone morphogenetic protein was used, and children who had a combination of the Ilizarov technique and intramedullary nailing were at risk for unsound union at maturity (odds ratio, 6.19; 95% confidence interval, 1.24-30.83; P=0.026). No other association reached statistical significance. On recursive partitioning, use of the Ilizarov technique, transfixing the ankle and subtalar joints, use of cortical graft and not operating on the fibula were associated with a better outcome; use of bone morphogenetic protein and combining intramedullary nailing with the Ilizarov technique were associated with poor results. CONCLUSIONS: A larger sample is needed to confirm which factors truly influence the outcome of CPT. This may be feasible if data are collected prospectively through a multicenter registry.
OBJECTIVE: To identify factors influencing union of congenital pseudarthrosis of the tibia (CPT), refractures, and integrity of the tibia at maturity. METHODS: Data of 119 children operated for Crawford-type IV CPT and followed-up till skeletal maturity were analyzed. Logistic regression and recursive partitioning analyses were used to test associations between several variables and the outcome. RESULTS: Primary union occurred in 86% of children. At maturity, 69% remained soundly united. The odds ratio for failure of primary union was 3.89 (95% confidence interval, 1.05-14.40; P=0.042) when bone morphogenetic protein was used, and children who had a combination of the Ilizarov technique and intramedullary nailing were at risk for unsound union at maturity (odds ratio, 6.19; 95% confidence interval, 1.24-30.83; P=0.026). No other association reached statistical significance. On recursive partitioning, use of the Ilizarov technique, transfixing the ankle and subtalar joints, use of cortical graft and not operating on the fibula were associated with a better outcome; use of bone morphogenetic protein and combining intramedullary nailing with the Ilizarov technique were associated with poor results. CONCLUSIONS: A larger sample is needed to confirm which factors truly influence the outcome of CPT. This may be feasible if data are collected prospectively through a multicenter registry.