| Literature DB >> 2966482 |
P L Durette1, J Boger, F Dumont, R Firestone, R A Frankshun, S L Koprak, C S Lin, M R Melino, A A Pessolano, J Pisano.
Abstract
In order to establish whether CyP is the pharmacologically relevant CsA receptor, the CyP binding v immunosuppressive activity was measured for an extensive, structurally varied group of CsA analogues. Overall, CyP binding was found to parallel immunosuppressive activity. Other than MeAla6-CsA, the few exceptions to the correlation could be ascribed to cellular metabolism. These results strongly implicate CyP or a related protein in the mechanism of action of cyclosporine.Entities:
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Year: 1988 PMID： 2966482
Source DB: PubMed Journal: Transplant Proc ISSN： 0041-1345 Impact factor: 1.066