Literature DB >> 29664646

Electrosynthesis of Trisubstituted 2-Oxazolines via Dehydrogenative Cyclization of β-Amino Arylketones.

Huiqiao Wang1, Jinjin Zhang1, Jiajing Tan2, Lilan Xin1, Yaping Li1, Sheng Zhang1, Kun Xu1.   

Abstract

An electrochemically intramolecular functionalization of C(sp3)-H bonds with masked oxygen nucleophiles was developed. With KI as the catalyst and electrolyte, diverse trisubstituted 2-oxazolines were constructed in good to excellent yields. This newly developed electrochemical dehydrogenative approach features external oxidant-free and additive-free conditions.

Entities:  

Year:  2018        PMID： 29664646     DOI： 10.1021/acs.orglett.8b00165

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Merging Photochemistry with Electrochemistry: Functional-Group Tolerant Electrochemical Amination of C(sp3 )-H Bonds.

Authors:  Fei Wang; Shannon S Stahl
Journal:  Angew Chem Int Ed Engl       Date:  2019-03-14       Impact factor: 15.336

Review 2.  Metal-Free Synthesis of N-Heterocycles via Intramolecular Electrochemical C-H Aminations.

Authors:  Huiqiao Wang; Yongjun Zheng; Hucheng Xu; Jiaru Zou; Congrui Jin
Journal:  Front Chem       Date:  2022-06-20       Impact factor: 5.545

3.  KO t Bu-promoted oxidative dimerizations of 2-methylquinolines to 2-alkenyl bisquinolines with molecular oxygen.

Authors:  Zhen Wang; Jinjin Zhang; Jianxue Shi; Huiqiao Wang
Journal:  RSC Adv       Date:  2019-09-23       Impact factor: 4.036

4.  Stereoselective synthesis of sulfur-containing β-enaminonitrile derivatives through electrochemical Csp3-H bond oxidative functionalization of acetonitrile.

Authors:  Tian-Jun He; Zongren Ye; Zhuofeng Ke; Jing-Mei Huang
Journal:  Nat Commun       Date:  2019-02-19       Impact factor: 14.919

5.  A mild catalytic synthesis of 2-oxazolines via oxetane ring-opening: rapid access to a diverse family of natural products.

Authors:  Hai Huang; Wen Yang; Zuliang Chen; Zengwei Lai; Jianwei Sun
Journal:  Chem Sci       Date:  2019-08-26       Impact factor: 9.825

6.  Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp3)-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium.

Authors:  Zhenghong Zhou; Kangfei Hu; Jiawei Wang; Zhibin Li; Yan Zhang; Zhenggen Zha; Zhiyong Wang
Journal:  ACS Omega       Date:  2020-12-01

7.  Facile Electrochemical Intramolecular Amination of Urea-Tethered Terminal Alkenes for the Synthesis of Cyclic Ureas.

Authors:  Nisar Ahmed; Saira Khatoon
Journal:  ChemistryOpen       Date:  2018-07-09       Impact factor: 2.911
  7 in total

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