Danielle M Graef1, Valerie McLaughlin Crabtree1, Deo Kumar Srivastava2, Chenghong Li2, Michele Pritchard3, Pamela S Hinds4,5, Belinda Mandrell3. 1. Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN, USA. 2. Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA. 3. Department of Pediatric Medicine, Division of Nursing Research, St. Jude Children's Research Hospital, Memphis, TN, USA. 4. Department of Nursing Research and Quality Outcomes, Children's National Health System, Memphis, TN, USA. 5. Department of Pediatrics, George Washington University Washington, District of Columbia, Washington, DC, USA.
Abstract
OBJECTIVE: Disrupted sleep is common in pediatric cancer, which is associated with psychological distress and may impact neural recovery. Information regarding sleep during pediatric brain tumor treatment is limited. This study aimed to describe objective sleep-wake patterns and examine the sleep-mood relation in youth hospitalized for intensive chemotherapy and stem cell rescue. METHODS: Participants included 37 patients (M age = 9.6 ± 4.2 years) enrolled on a medulloblastoma protocol (SJMB03) and their parents. Respondents completed a mood disturbance measure on 3 days, and patients wore an actigraph for 5 days as an objective estimate of sleep-wake patterns. General linear mixed models examined the relation between nocturnal sleep and next-day mood, as well as mood and that night's sleep. RESULTS: Sleep duration was deficient, sleep efficiency was poor, and daytime napping was common, with large between-subjects variability. There were minimal mood concerns across all days. The sleep and next-day mood relationship was nonsignificant (P > .05). Greater parent-reported child mood disturbance on day 2 was associated with decreased same-night sleep (P < .001) and greater patient-reported mood disturbance was associated with greater same-night sleep latency (P = .036). CONCLUSIONS: Patients with medulloblastoma are vulnerable to disturbed sleep during hospitalization, and mood may be an important correlate to consider. Sleep and mood are modifiable factors that may be targeted to maximize daytime functioning.
OBJECTIVE: Disrupted sleep is common in pediatric cancer, which is associated with psychological distress and may impact neural recovery. Information regarding sleep during pediatric brain tumor treatment is limited. This study aimed to describe objective sleep-wake patterns and examine the sleep-mood relation in youth hospitalized for intensive chemotherapy and stem cell rescue. METHODS:Participants included 37 patients (M age = 9.6 ± 4.2 years) enrolled on a medulloblastoma protocol (SJMB03) and their parents. Respondents completed a mood disturbance measure on 3 days, and patients wore an actigraph for 5 days as an objective estimate of sleep-wake patterns. General linear mixed models examined the relation between nocturnal sleep and next-day mood, as well as mood and that night's sleep. RESULTS: Sleep duration was deficient, sleep efficiency was poor, and daytime napping was common, with large between-subjects variability. There were minimal mood concerns across all days. The sleep and next-day mood relationship was nonsignificant (P > .05). Greater parent-reported child mood disturbance on day 2 was associated with decreased same-night sleep (P < .001) and greater patient-reported mood disturbance was associated with greater same-night sleep latency (P = .036). CONCLUSIONS:Patients with medulloblastoma are vulnerable to disturbed sleep during hospitalization, and mood may be an important correlate to consider. Sleep and mood are modifiable factors that may be targeted to maximize daytime functioning.
Authors: Belinda N Mandrell; Merrill Wise; Robert A Schoumacher; Michele Pritchard; Nancy West; Kirsten K Ness; Valerie McLaughlin Crabtree; Thomas E Merchant; Brannon Morris Journal: Pediatr Blood Cancer Date: 2011-10-18 Impact factor: 3.167
Authors: Yin Ting Cheung; Tara M Brinkman; Chenghong Li; Yasmin Mzayek; Deokumar Srivastava; Kirsten K Ness; Sunita K Patel; Rebecca M Howell; Kevin C Oeffinger; Leslie L Robison; Gregory T Armstrong; Kevin R Krull Journal: J Natl Cancer Inst Date: 2018-04-01 Impact factor: 13.506
Authors: Michele A Bertocci; Ronald E Dahl; Douglas E Williamson; Ana-Maria Iosif; Boris Birmaher; David Axelson; Neal D Ryan Journal: J Am Acad Child Adolesc Psychiatry Date: 2005-11 Impact factor: 8.829
Authors: Kris Ann P Schultz; Kirsten K Ness; John Whitton; Christopher Recklitis; Brad Zebrack; Leslie L Robison; Lonnie Zeltzer; Ann C Mertens Journal: J Clin Oncol Date: 2007-08-20 Impact factor: 50.717
Authors: Brad J Zebrack; James G Gurney; Kevin Oeffinger; John Whitton; Roger J Packer; Ann Mertens; Norman Turk; Robert Castleberry; ZoAnn Dreyer; Leslie L Robison; Lonnie K Zeltzer Journal: J Clin Oncol Date: 2004-03-15 Impact factor: 50.717
Authors: Xi Luo; Qin Xie; Qiuling Shi; Yan Miao; Qingsong Yu; Hongfan Yu; Hong Yin; Xuefeng Leng; Yongtao Han; Hong Zhou Journal: Support Care Cancer Date: 2021-11-24 Impact factor: 3.603
Authors: Lauren C Daniel; Raphaele R L van Litsenburg; Valerie E Rogers; Eric S Zhou; Sarah J Ellis; Claire E Wakefield; Robyn Stremler; Lisa Walter; Valerie McLaughlin Crabtree Journal: Psychooncology Date: 2019-11-03 Impact factor: 3.955