Role of oocyte-specific genes in the development of mammalian embryos.

Studies on oocyte-specific genes are important in understanding the genetic pathways essential for folliculogenesis, oogenesis and early embryogenesis. Although the molecular mechanisms regulating oocyte growth and embryo development in mammals have partially been unraveled by gene knockout studies, many aspects concerning reproduction remain to be determined. Development of mammalian embryos starts with the fusion of sperm and egg. After fertilization, the first major developmental transition, maternal to zygotic transition, occurs at the specific stages of preimplantation development in each mammal. The transition is called zygotic gene activation (ZGA) or embryonic genome activation. The ZGA is one of the most important events that occur during preimplantation development; however, the mechanism of the event remains unknown. Because the development until the transition is maintained by maternally inherited proteins and transcripts stored in the oocytes, it is highly likely that these products play an important role in the initiation of ZGA. Several maternal-effects genes that are specifically expressed in oocytes have been identified and their involvement in preimplantation development has been revealed. Therefore, to study oocyte-specific gene regulation would help not only to understand the precise mechanisms of mammalian development, but also to show the mechanisms of reproductive disorders, such as premature ovarian failure and infertility. (Reprod Med Biol 2006; 5: 175-182).