Xiaoniu Liang1,2, Zhao Chen3,4, Xinqi Dong5, Qianhua Zhao1,2, Qihao Guo1,2, Li Zheng1,2, Wei Deng3,4, Jianfeng Luo3,4, Ding Ding1,2. 1. 1 Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China. 2. 2 National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China. 3. 3 Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China. 4. 4 The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai, China. 5. 5 Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, USA.
Abstract
OBJECTIVE: The aim of this study is to explore the association between mental work demands (MWDs) and late-life cognition among Chinese older adults. METHOD: Data were drawn from the baseline of the Shanghai Aging Study. RESULTS: Among 3,546 participants, the mean MWDs index of participants with dementia, mild cognitive impairment (MCI), and cognitive normal were 2.8 ( SD = 0.5), 2.8 ( SD = 0.5), and 2.9 ( SD = 0.4), respectively. Mini Mental State Examination (MMSE) scores in group with low MWDs level decreased more dramatically by increasing age than that in groups with middle and high MWDs level ( p < .001). In a subgroup of participants with education ≥6 years, we found a positive correlation between MWDs index and MMSE score after adjusting for gender, age, body mass index, income, living alone, smoking, drinking, anxiety, depression, heart disease, hypertension, diabetes, and APOE-ε4 (apolipoprotein), by generalized linear model analysis ( p < .001). DISCUSSION: Our results suggest that long-time mental work stimulation during adulthood would have potential benefits to late-life cognition.
OBJECTIVE: The aim of this study is to explore the association between mental work demands (MWDs) and late-life cognition among Chinese older adults. METHOD: Data were drawn from the baseline of the Shanghai Aging Study. RESULTS: Among 3,546 participants, the mean MWDs index of participants with dementia, mild cognitive impairment (MCI), and cognitive normal were 2.8 ( SD = 0.5), 2.8 ( SD = 0.5), and 2.9 ( SD = 0.4), respectively. Mini Mental State Examination (MMSE) scores in group with low MWDs level decreased more dramatically by increasing age than that in groups with middle and high MWDs level ( p < .001). In a subgroup of participants with education ≥6 years, we found a positive correlation between MWDs index and MMSE score after adjusting for gender, age, body mass index, income, living alone, smoking, drinking, anxiety, depression, heart disease, hypertension, diabetes, and APOE-ε4 (apolipoprotein), by generalized linear model analysis ( p < .001). DISCUSSION: Our results suggest that long-time mental work stimulation during adulthood would have potential benefits to late-life cognition.
Authors: Andrea E Zülke; Melanie Luppa; Susanne Röhr; Marina Weißenborn; Alexander Bauer; Franziska-Antonia Zora Samos; Flora Kühne; Isabel Zöllinger; Juliane Döhring; Christian Brettschneider; Anke Oey; David Czock; Thomas Frese; Jochen Gensichen; Walter E Haefeli; Wolfgang Hoffmann; Hanna Kaduszkiewicz; Hans-Helmut König; Jochen René Thyrian; Birgitt Wiese; Steffi G Riedel-Heller Journal: BMC Geriatr Date: 2021-12-10 Impact factor: 3.921