Literature DB >> 2966078

Post-translational modification of the beta-subunit of the human fibronectin receptor.

M Jaspers1, B de Strooper, M Spaepen, F van Leuven, G David, H van den Berghe, J J Cassiman.   

Abstract

Monoclonal antibody DH12, directed against the beta-subunit of the fibronectin receptor recognizes a doublet of proteins (100 and 110 kDa) in Western blots of solubilized whole fibroblasts. Pulse-chase experiments with [35S]methionine in human skin fibroblasts suggested that the two proteins might be metabolically related as precursor (100 kDa) and product (110 kDa). Endo H digestion and [3H]fucose labeling suggested that maturation converted the high-mannose oligosaccharides (100 kDa) to the endoglycosidase H resistant complex type (110 kDa). This was supported by N-glycanase digestion and by chemical deglycosylation which showed a single polypeptide. Surface iodination of intact cells labeled only the presumed mature beta-subunit.

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Year:  1988        PMID： 2966078     DOI： 10.1016/0014-5793(88)80859-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

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Journal:  Br J Cancer       Date:  1990-04       Impact factor: 7.640

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Authors:  Shangyang She; Boying Xu; Min He; Xiuwan Lan; Qiuyan Wang
Journal:  J Exp Clin Cancer Res       Date:  2010-07-11

4.  Biosynthesis, surface expression and function of the fibronectin receptor after rat liver cell transformation to tumorigenicity.

Authors:  M Decastel; M A Doyennette-Moyne; E Gouet; M Aubery; P Codogno
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

5.  Carcinoembryonic antigen functions as an accessory adhesion molecule mediating colon epithelial cell-collagen interactions.

Authors:  M Pignatelli; H Durbin; W F Bodmer
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

6.  Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization.

Authors:  S K Akiyama; S S Yamada; W T Chen; K M Yamada
Journal:  J Cell Biol       Date:  1989-08       Impact factor: 10.539

7.  Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events.

Authors:  C T Basson; W J Knowles; L Bell; S M Albelda; V Castronovo; L A Liotta; J A Madri
Journal:  J Cell Biol       Date:  1990-03       Impact factor: 10.539

8.  Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation.

Authors:  Bethany Sanchez; Xixi Zhou; Amy S Gardiner; Guy Herbert; Selita Lucas; Masako Morishita; James G Wagner; Ryan Lewandowski; Jack R Harkema; Chris Shuey; Matthew J Campen; Katherine E Zychowski
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  8 in total

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