Literature DB >> 29660768

CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes.

Yujing Zhou1, Oliver D Engl1, Jeffrey S Bandar1, Emma D Chant1, Stephen L Buchwald1.   

Abstract

A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  alkenes; amidation; amides; copper; enantioselectivity

Mesh：

Substances：

Year:  2018        PMID： 29660768      PMCID： PMC5992098          DOI： 10.1002/anie.201802797

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  27 in total

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Review 10.  Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes.

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4.  Enantioselective Hydroamination of Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer.

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8.  Enantioselective synthesis of α-aminoboronates by NiH-catalysed asymmetric hydroamidation of alkenyl boronates.

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