Hui Sun1, Lizhu Luo2, Xinru Yuan2, Lu Zhang3, Yini He2, Shuqiao Yao4, Jiaojian Wang5, Jing Xiao6. 1. Beijing Key Laboratory of Learning and Cognition, School of Education, Capital Normal University, Beijing 100048, China. 2. The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 625014, China. 3. Graduate School of Education, Peking University, Beijing 100871, China. 4. Medical Psychological Research Center, Second Xiangya Hospital, Central South University, Changsha 410011, China. 5. The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 625014, China. Electronic address: jiaojianwang@uestc.edu.cn. 6. Beijing Key Laboratory of Learning and Cognition, School of Education, Capital Normal University, Beijing 100048, China. Electronic address: xiaojingcnu@163.com.
Abstract
BACKGROUND: Cognitive vulnerability to depression (CVD) is a high risk for depressive disorder. Recent studies focus on individuals with CVD to determine the neural basis of major depressive disorder (MDD) neuropathology. However, whether CVD showed specific or similar brain functional activity and connectivity patterns, compared to MDD, remain largely unknown. METHODS: Here, using resting-state functional magnetic resonance imaging in subjects with CVD, healthy controls (HC) and MDD, regional homogeneity (ReHo) and resting-state functional connectivity (R-FC) analyses were conducted to assess local synchronization and changes in functional connectivity patterns. RESULTS: Significant ReHo differences were found in right posterior lobe of cerebellum (PLC), left lingual gyrus (LG) and precuneus. Compared to HC, CVD subjects showed increased ReHo in the PLC, which was similar to the difference found between MDD and HC. Compared to MDD patients, CVD subjects showed decreased ReHo in PLC, LG, and precuneus. R-FC analyses found increased functional connections between LG and left inferior parietal lobule, posterior cingulate cortex, and dorsolateral prefrontal cortex in CVD compared to both HC and MDD. Moreover, Regional mean ReHo values were positively correlated with Center for Epidemiologic Studies Depression Scale scores. CONCLUSION: These analyses revealed that PLC and functional connections between LG and left inferior parietal lobule, posterior cingulate cortex, and dorsolateral prefrontal cortex may be a potential marker for CVD.
BACKGROUND:Cognitive vulnerability to depression (CVD) is a high risk for depressive disorder. Recent studies focus on individuals with CVD to determine the neural basis of major depressive disorder (MDD) neuropathology. However, whether CVD showed specific or similar brain functional activity and connectivity patterns, compared to MDD, remain largely unknown. METHODS: Here, using resting-state functional magnetic resonance imaging in subjects with CVD, healthy controls (HC) and MDD, regional homogeneity (ReHo) and resting-state functional connectivity (R-FC) analyses were conducted to assess local synchronization and changes in functional connectivity patterns. RESULTS: Significant ReHo differences were found in right posterior lobe of cerebellum (PLC), left lingual gyrus (LG) and precuneus. Compared to HC, CVD subjects showed increased ReHo in the PLC, which was similar to the difference found between MDD and HC. Compared to MDDpatients, CVD subjects showed decreased ReHo in PLC, LG, and precuneus. R-FC analyses found increased functional connections between LG and left inferior parietal lobule, posterior cingulate cortex, and dorsolateral prefrontal cortex in CVD compared to both HC and MDD. Moreover, Regional mean ReHo values were positively correlated with Center for Epidemiologic Studies Depression Scale scores. CONCLUSION: These analyses revealed that PLC and functional connections between LG and left inferior parietal lobule, posterior cingulate cortex, and dorsolateral prefrontal cortex may be a potential marker for CVD.
Authors: Sheeba Arnold Anteraper; Xavier Guell; Yoon Ji Lee; Jovicarole Raya; Ilya Demchenko; Nathan W Churchill; Benicio N Frey; Stefanie Hassel; Raymond W Lam; Glenda M MacQueen; Roumen Milev; Tom A Schweizer; Stephen C Strother; Susan Whitfield-Gabrieli; Sidney H Kennedy; Venkat Bhat Journal: Cerebellum Date: 2022-01-13 Impact factor: 3.847