BACKGROUND: Stenting and flow diversion for aneurysmal sub arachnoid hemorrhage (aSAH) require the use of dual antiplatelet therapy (DAPT). OBJECTIVE: To investigate whether DAPT is associated with hemorrhagic complication following placement of external ventricular drains (EVD) in patients with aSAH. METHODS: Rates of radiographically identified hemorrhage associated with EVD placement were compared between patients who received DAPT for stenting or flow diversion, and patients who underwent microsurgical clipping or coiling and did not receive DAPT by way of a backward stepwise multivariate analysis. RESULTS: Four hundred forty-three patients were admitted for aSAH management. Two hundred ninety-eight patients required placement of an EVD. One hundred twenty patients (40%) were treated with stent-assisted coiling or flow diversion and required DAPT, while 178 patients (60%) were treated with coiling without stents or microsurgical clipping and did not receive DAPT. Forty-two (14%) cases of new hemorrhage along the EVD catheter were identified radiographically. Thirty-two of these hemorrhages occurred in patients on DAPT, while 10 occurred in patients without DAPT. After multivariate analysis, DAPT was significantly associated with radiographic hemorrhage [odds ratio: 4.92, 95% confidence interval: 2.45-9.91, P = .0001]. We did not observe an increased proportion of symptomatic hemorrhage in patients receiving DAPT (10 of 32 [31%]) vs those without (5 of 10 [50%]; P = .4508). CONCLUSION: Patients with aSAH who receive stent-assisted coiling or flow diversion are at higher risk for radiographic hemorrhage associated with EVD placement. The timing between EVD placement and DAPT initiation does not appear to be of clinical significance. Stenting and flow diversion remain viable options for aSAH patients.
BACKGROUND: Stenting and flow diversion for aneurysmal sub arachnoid hemorrhage (aSAH) require the use of dual antiplatelet therapy (DAPT). OBJECTIVE: To investigate whether DAPT is associated with hemorrhagic complication following placement of external ventricular drains (EVD) in patients with aSAH. METHODS: Rates of radiographically identified hemorrhage associated with EVD placement were compared between patients who received DAPT for stenting or flow diversion, and patients who underwent microsurgical clipping or coiling and did not receive DAPT by way of a backward stepwise multivariate analysis. RESULTS: Four hundred forty-three patients were admitted for aSAH management. Two hundred ninety-eight patients required placement of an EVD. One hundred twenty patients (40%) were treated with stent-assisted coiling or flow diversion and required DAPT, while 178 patients (60%) were treated with coiling without stents or microsurgical clipping and did not receive DAPT. Forty-two (14%) cases of new hemorrhage along the EVD catheter were identified radiographically. Thirty-two of these hemorrhages occurred in patients on DAPT, while 10 occurred in patients without DAPT. After multivariate analysis, DAPT was significantly associated with radiographic hemorrhage [odds ratio: 4.92, 95% confidence interval: 2.45-9.91, P = .0001]. We did not observe an increased proportion of symptomatic hemorrhage in patients receiving DAPT (10 of 32 [31%]) vs those without (5 of 10 [50%]; P = .4508). CONCLUSION:Patients with aSAH who receive stent-assisted coiling or flow diversion are at higher risk for radiographic hemorrhage associated with EVD placement. The timing between EVD placement and DAPT initiation does not appear to be of clinical significance. Stenting and flow diversion remain viable options for aSAH patients.
Authors: Kaustubh Limaye; Mario Zanaty; Joseph Hudson; Daichi Nakagawa; Sami Al Kasab; Carlos Alvarez; Sudeepta Dandapat; David K Kung; Santiago Ortega-Gutierrez; Pascal Jabbour; Edgar A Samaniego; David Hasan Journal: Neurosurgery Date: 2019-12-01 Impact factor: 4.654
Authors: J M Ospel; P Brouwer; F Dorn; A Arthur; M E Jensen; R Nogueira; R Chapot; F Albuquerque; C Majoie; M Jayaraman; A Taylor; J Liu; J Fiehler; N Sakai; K Orlov; D Kallmes; J F Fraser; L Thibault; M Goyal Journal: AJNR Am J Neuroradiol Date: 2020-09-17 Impact factor: 3.825
Authors: Sarah E Nelson; Jose I Suarez; Alexander Sigmon; Jun Hua; Casey Weiner; Haris I Sair; Robert D Stevens Journal: Neurol Res Pract Date: 2022-06-27
Authors: Mario Zanaty; Jorge A Roa; Stavropoula I Tjoumakaris; Pascal Jabbour; Nikolaos Mouchtouris; Ahmad Sweid; Santiago Ortega-Gutierrez; Daizo Ishii; Kaustubh Limaye; Khaled Asi; Edgar A Samaniego; David M Hasan Journal: World Neurosurg Date: 2019-11-20 Impact factor: 2.104
Authors: Daizo Ishii; Luyuan Li; Mario Zanaty; Jorge A Roa; Lauren Allan; Edgar A Samaniego; David M Hasan Journal: Interv Neuroradiol Date: 2020-06-17 Impact factor: 1.610
Authors: Edgar A Samaniego; Emilee Gibson; Daichi Nakagawa; Santiago Ortega-Gutierrez; Mario Zanaty; Jorge A Roa; Pascal Jabbour; David M Hasan Journal: Stroke Vasc Neurol Date: 2019-02-03
Authors: Moritz Lenschow; Niklas von Spreckelsen; Sergej Telentschak; Christoph Kabbasch; Roland Goldbrunner; Stefan Grau Journal: Neurosurg Rev Date: 2022-04-29 Impact factor: 2.800
Authors: Claudia Ditz; Björn Machner; Hannes Schacht; Alexander Neumann; Peter Schramm; Volker M Tronnier; Jan Küchler Journal: Neurosurg Rev Date: 2021-01-25 Impact factor: 3.042