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Literature DB >> 29657877

Semaphorin3A: A potential therapeutic tool in immune-mediated diseases.

Abstract

The significance of semaphorin3A (sema3A) in regulating immune-mediated inflammation is widely reported. There are multiple mechanisms involved in the process of sema3A-mediated regulation. One of them is the ability of sema3A to maintain a sufficient regulation of both T-cell and B-cell activation. Because it is involved in the pathogenesis of many autoimmune, infectious, and malignant diseases, sema3A turns to be a promising therapeutic tool to be studied and applied in these diseases.

Entities: Disease Gene

Keywords: Semaphorin 3A; atopic diseases; immune mediated diseases

Year: 2017 PMID： 29657877 PMCID： PMC5895154 DOI： 10.5152/eurjrheum.2017.17076

Source DB: PubMed Journal: Eur J Rheumatol ISSN： 2147-9720

24 in total

Review 1. Neuropilins, semaphorins, and their role in thymocyte development.

Authors: Daniella Arêas Mendes-da-Cruz; Yves Lepelletier; Anne C Brignier; Salete Smaniotto; Amédée Renand; Pierre Milpied; Mireille Dardenne; Olivier Hermine; Wilson Savino
Journal: Ann N Y Acad Sci Date: 2009-02 Impact factor: 5.691

2. The Involvement of Immune Semaphorins in the Pathogenesis of Inflammatory Bowel Diseases (IBDs).

Authors: Zahava Vadasz; Tova Rainis; Afif Nakhleh; Tharwat Haj; Jacob Bejar; Katty Halasz; Elias Toubi
Journal: PLoS One Date: 2015-05-15 Impact factor: 3.240

3. Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis.

Authors: Osamu Negi; Mitsutoshi Tominaga; Suhandy Tengara; Atsuko Kamo; Kenichi Taneda; Yasushi Suga; Hideoki Ogawa; Kenji Takamori
Journal: J Dermatol Sci Date: 2012-01-21 Impact factor: 4.563

4. Semaphorin 3A: an immunoregulator in systemic sclerosis.

Authors: Doron Rimar; Yuval Nov; Itzhak Rosner; Gleb Slobodin; Michael Rozenbaum; Katy Halasz; Tharwat Haj; Nizar Jiries; Lisa Kaly; Nina Boulman; Zahava Vadasz
Journal: Rheumatol Int Date: 2015-04-21 Impact factor: 2.631

5. Intranasal administration of semaphorin-3A alleviates sneezing and nasal rubbing in a murine model of allergic rhinitis.

Authors: Haruna Sawaki; Fumio Nakamura; Michiko Aihara; Yoji Nagashima; Junko Komori-Yamaguchi; Naoya Yamashita; Masatoshi Nakazawa; Yoshio Goshima; Zenro Ikezawa
Journal: J Pharmacol Sci Date: 2011-08-18 Impact factor: 3.337

6. Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis.

Authors: Junmi Tanaka; Hideo Tanaka; Nobuhisa Mizuki; Eiichi Nomura; Norihiko Ito; Naoko Nomura; Masayuki Yamane; Tomonobu Hida; Yoshio Goshima; Hiroshi Hatano; Hisashi Nakagawa
Journal: Int J Ophthalmol Date: 2015-02-18 Impact factor: 1.779

7. A regulatory role for CD72 expression on B cells in systemic lupus erythematosus.

Authors: Zahava Vadasz; Tharwat Haj; Alexandra Balbir; Regina Peri; Itzhak Rosner; Gleb Slobodin; Aharon Kessel; Elias Toubi
Journal: Semin Arthritis Rheum Date: 2013-12-04 Impact factor: 5.532

8. Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts.

Authors: Simona Moretti; Antonio Procopio; Raffaella Lazzarini; Maria Rita Rippo; Roberto Testa; Maurizio Marra; Luca Tamagnone; Alfonso Catalano
Journal: Blood Date: 2007-12-03 Impact factor: 22.113

9. Decreased semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis.

Authors: Shu Takagawa; Fumio Nakamura; Ken Kumagai; Yoji Nagashima; Yoshio Goshima; Tomoyuki Saito
Journal: BMC Musculoskelet Disord Date: 2013-01-23 Impact factor: 2.362

Review 10. The semaphorins.

Authors: Umar Yazdani; Jonathan R Terman
Journal: Genome Biol Date: 2006-03-30 Impact factor: 13.583

4 in total