E Thomas1, A Bertolotti2, A Barreau1, J Klisnick2, P Tournebize3, G Borgherini2, N Zemali1, J Jaubert1, G Jouvion4, S Bretagne5, S Picot6. 1. Service de bactériologie, virologie, parasitologie, centre hospitalier universitaire de La Réunion, site Sud, BP 350, 97448 Saint-Pierre cedex, Reunion. 2. Service de maladies infectieuses, centre hospitalier universitaire de La Réunion, site Sud, BP 350, 97448 Saint-Pierre cedex, Reunion. 3. Service de neurologie, centre hospitalier universitaire de La Réunion, site Sud, BP 350, 97448 Saint-Pierre cedex, Reunion. 4. Institut Pasteur, histopathologie humaine et modèles animaux, 28, rue du Docteur-Roux, 75015 Paris, France. 5. Institut Pasteur, centre national de référence des mycoses invasives et des antifongiques, 28, rue du Docteur-Roux, 75015 Paris, France. 6. Service de bactériologie, virologie, parasitologie, centre hospitalier universitaire de La Réunion, site Sud, BP 350, 97448 Saint-Pierre cedex, Reunion. Electronic address: sandrine.picot@chu-reunion.fr.
Abstract
OBJECTIVE: Infections caused by dematiaceous fungi are more common in tropical and subtropical areas. We aimed to describe the clinical, microbiological and therapeutic aspects of case patients diagnosed at a University Hospital located on an Indian Ocean island. PATIENTS AND METHODS: We performed an observational retrospective study of infections caused by dematiaceous fungi diagnosed at the University Hospital of Saint-Pierre, Reunion, from 2000 to 2015. Mycological identifications were performed at the National Reference Center for Invasive Mycosis and Antifungal Agents (Paris). RESULTS: The review of clinical and microbiological data of 11 patients identified revealed that five were infected by dematiaceous fungi. Two had cutaneous phaeohyphomycosis, two had cerebral phaeohyphomycosis and one had cutaneous chromoblastomycosis with brain and potentially medullary dissemination. Skin lesions and cerebral abscesses were quite varied. CONCLUSION: Infections caused by dematiaceous fungi are rare. Medullary and brain localizations are extremely rare, especially for chromoblastomycosis. Cutaneous manifestations of phaeohyphomycosis are varied; diagnosis is thus more difficult. It is therefore important, when confronted with a chronic tumor-like lesion in endemic areas, to perform a biopsy for pathology and fungal culture. While surgical excision is not always sufficient, medical treatment of these infections is not standardized, but relies on an azole, which can be associated with another antifungal agent.
OBJECTIVE:Infections caused by dematiaceous fungi are more common in tropical and subtropical areas. We aimed to describe the clinical, microbiological and therapeutic aspects of case patients diagnosed at a University Hospital located on an Indian Ocean island. PATIENTS AND METHODS: We performed an observational retrospective study of infections caused by dematiaceous fungi diagnosed at the University Hospital of Saint-Pierre, Reunion, from 2000 to 2015. Mycological identifications were performed at the National Reference Center for Invasive Mycosis and Antifungal Agents (Paris). RESULTS: The review of clinical and microbiological data of 11 patients identified revealed that five were infected by dematiaceous fungi. Two had cutaneous phaeohyphomycosis, two had cerebral phaeohyphomycosis and one had cutaneous chromoblastomycosis with brain and potentially medullary dissemination. Skin lesions and cerebral abscesses were quite varied. CONCLUSION:Infections caused by dematiaceous fungi are rare. Medullary and brain localizations are extremely rare, especially for chromoblastomycosis. Cutaneous manifestations of phaeohyphomycosis are varied; diagnosis is thus more difficult. It is therefore important, when confronted with a chronic tumor-like lesion in endemic areas, to perform a biopsy for pathology and fungal culture. While surgical excision is not always sufficient, medical treatment of these infections is not standardized, but relies on an azole, which can be associated with another antifungal agent.
Authors: Perceus Mody; Paul Wada; Karen C Bloch; Michail S Lionakis; Katie D White; Alexander S Maris; Tonya Snyder; Jennifer Steinhauer; Romney Humphries Journal: BMC Infect Dis Date: 2022-01-04 Impact factor: 3.090
Authors: Rowena Alves Coelho; Gabriela Machado Alves; Maria Helena Galdino Figueiredo-Carvalho; Fernando Almeida-Silva; Gabriela Rodrigues de Souza; Maria Cristina da Silva Lourenço; Fábio Brito-Santos; Ana Claudia Fernandes Amaral; Rodrigo Almeida-Paes Journal: Mem Inst Oswaldo Cruz Date: 2022-09-12 Impact factor: 2.747