Xin He1, Chen Liu1, Yili Chen1, Jiangui He1, Yugang Dong2. 1. Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, and Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, China. 2. Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, and Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, China. Electronic address: dongxg@mail.sysu.edu.cn.
Abstract
OBJECTIVE: To assess the association of overweight without central obesity with risks of mortality. PATIENTS AND METHODS: We included 14,299 participants in the Third National Health and Nutrition Examination Survey (from October 18, 1988, through October 15, 1994). According to their body mass index and waist circumference, participants were categorized into 7 anthropometric groups. Logistic regression models were used to assess the relation of cardiovascular risk factors (hypertension, diabetes, or hypercholesterolemia) and 10-year cardiovascular risk to anthropometric groups. Cox proportional hazards models were used to assess the risk of all-cause mortality, and competing-risks regression models were used for calculating cardiovascular and noncardiovascular mortality. RESULTS: Compared with those with normal body mass index and waist circumference, overweight men without central obesity were more likely to have all 3 cardiovascular risk factors and a high cardiovascular risk, whereas women in this anthropometric group were more likely to have hypercholesterolemia. In proportional hazards models, overweight without central obesity was associated with lower all-cause mortality among men in the population with cardiovascular risk factors (hazard ratio, 0.71; 95% CI, 0.56-0.89; P=.004) and the general population (hazard ratio, 0.72; 95% CI, 0.60-0.87; P=.001), whereas results of these comparisons among women were not significant (P>.05). In competing risk analyses, overweight men without central obesity had a lower risk of noncardiovascular mortality, but not cardiovascular mortality. CONCLUSION: Although overweight without central obesity was associated with cardiovascular risk factors and a high cardiovascular risk among men, men in this anthropometric group had a lower mortality risk.
OBJECTIVE: To assess the association of overweight without central obesity with risks of mortality. PATIENTS AND METHODS: We included 14,299 participants in the Third National Health and Nutrition Examination Survey (from October 18, 1988, through October 15, 1994). According to their body mass index and waist circumference, participants were categorized into 7 anthropometric groups. Logistic regression models were used to assess the relation of cardiovascular risk factors (hypertension, diabetes, or hypercholesterolemia) and 10-year cardiovascular risk to anthropometric groups. Cox proportional hazards models were used to assess the risk of all-cause mortality, and competing-risks regression models were used for calculating cardiovascular and noncardiovascular mortality. RESULTS: Compared with those with normal body mass index and waist circumference, overweight men without central obesity were more likely to have all 3 cardiovascular risk factors and a high cardiovascular risk, whereas women in this anthropometric group were more likely to have hypercholesterolemia. In proportional hazards models, overweight without central obesity was associated with lower all-cause mortality among men in the population with cardiovascular risk factors (hazard ratio, 0.71; 95% CI, 0.56-0.89; P=.004) and the general population (hazard ratio, 0.72; 95% CI, 0.60-0.87; P=.001), whereas results of these comparisons among women were not significant (P>.05). In competing risk analyses, overweight men without central obesity had a lower risk of noncardiovascular mortality, but not cardiovascular mortality. CONCLUSION: Although overweight without central obesity was associated with cardiovascular risk factors and a high cardiovascular risk among men, men in this anthropometric group had a lower mortality risk.
Authors: Yen How Tan; Jun Pei Lim; Wee Shiong Lim; Fei Gao; Louis L Y Teo; See Hooi Ewe; Bryan M H Keng; Ru San Tan; Woon-Puay Koh; Angela S Koh Journal: Obes Facts Date: 2022-03-04 Impact factor: 4.807