Literature DB >> 29656508

The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond":Unresolved questions, challenges and future directions for the field.

Michael N Lehman1, Lique M Coolen2, Robert A Steiner3, Genevieve Neal-Perry3, Luhong Wang4, Suzanne M Moenter4,5, Aleisha M Moore1, Robert L Goodman6, Shel Hwa-Yeo7, Stephanie L Padilla8, Alexander S Kauffman9, James Garcia10, Martin J Kelly11, Jenny Clarkson12, Sally Radovick13, Andy V Babwah13, Silvia Leon14, Manuel Tena-Sempere15, Alex Comninos16, Stephanie Seminara17, Waljit S Dhillo16, Jon Levine18,19, Ei Terasawa18,20, Ariel Negron13, Allan E Herbison12.   

Abstract

The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond" was held March 30-31 at the Rosen Centre Hotel in Orlando, Florida, providing an international forum for multidisciplinary scientists to meet and share cutting-edge research on kisspeptin biology and its relevance to human health and disease. The meeting built upon previous world conferences focused on the role of kisspeptin and associated peptides in the control of gonadotropin-releasing hormone (GnRH) secretion and reproduction. Based on recent discoveries, the scope of this meeting was expanded to include functions of kisspeptin and related peptides in other physiological systems including energy homeostasis, pregnancy, ovarian and uterine function, and thermoregulation. In addition, discussions addressed the translation of basic knowledge of kisspeptin biology to the treatment of disease, with the goal of seeking consensus about the best approaches to improve human health. The two-day meeting featured a non-traditional structure, with each day starting with poster sessions followed by lunch discussions and facilitated large-group sessions with short presentations to maximize the exchange of new, unpublished data. Topics were identified by a survey prior to the meeting, and focused on major unresolved questions, important controversies, and future directions in the field. Finally, career development activities provided mentoring for trainees and junior investigators, and networking opportunities for those individuals with established researchers in the field. Overall, the meeting was rated as a success by attendees and covered a wide range of lively and provocative discussion topics on the changing nature of the field of "kisspeptinology" and its future. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Entities:  

Keywords:  Conference; GnRH; International; Kisspeptin; Neuroendocrine

Year:  2018        PMID: 29656508      PMCID: PMC6461527          DOI: 10.1111/jne.12600

Source DB:  PubMed          Journal:  J Neuroendocrinol        ISSN: 0953-8194            Impact factor:   3.870


  94 in total

1.  Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.

Authors:  E L Thompson; M Patterson; K G Murphy; K L Smith; W S Dhillo; J F Todd; M A Ghatei; S R Bloom
Journal:  J Neuroendocrinol       Date:  2004-10       Impact factor: 3.627

2.  Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse.

Authors:  Simon de Croft; Ulrich Boehm; Allan E Herbison
Journal:  Endocrinology       Date:  2013-06-06       Impact factor: 4.736

3.  Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia.

Authors:  N M Page; R J Woods; S M Gardiner; K Lomthaisong; R T Gladwell; D J Butlin; I T Manyonda; P J Lowry
Journal:  Nature       Date:  2000-06-15       Impact factor: 49.962

4.  The GPR54 gene as a regulator of puberty.

Authors:  Stephanie B Seminara; Sophie Messager; Emmanouella E Chatzidaki; Rosemary R Thresher; James S Acierno; Jenna K Shagoury; Yousef Bo-Abbas; Wendy Kuohung; Kristine M Schwinof; Alan G Hendrick; Dirk Zahn; John Dixon; Ursula B Kaiser; Susan A Slaugenhaupt; James F Gusella; Stephen O'Rahilly; Mark B L Carlton; William F Crowley; Samuel A J R Aparicio; William H Colledge
Journal:  N Engl J Med       Date:  2003-10-23       Impact factor: 91.245

Review 5.  Keeping puberty on time: novel signals and mechanisms involved.

Authors:  Manuel Tena-Sempere
Journal:  Curr Top Dev Biol       Date:  2013       Impact factor: 4.897

6.  Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure.

Authors:  Mauricio D Dorfman; Cecilia Garcia-Rudaz; Zefora Alderman; Bredford Kerr; Alejandro Lomniczi; Gregory A Dissen; Juan Manuel Castellano; David Garcia-Galiano; Francisco Gaytan; Baoji Xu; Manuel Tena-Sempere; Sergio R Ojeda
Journal:  Endocrinology       Date:  2014-05-30       Impact factor: 4.736

7.  Neuroestradiol in the hypothalamus contributes to the regulation of gonadotropin releasing hormone release.

Authors:  Brian P Kenealy; Amita Kapoor; Kathryn A Guerriero; Kim L Keen; James P Garcia; Joseph R Kurian; Toni E Ziegler; Ei Terasawa
Journal:  J Neurosci       Date:  2013-12-04       Impact factor: 6.167

8.  Kiss1 mutant placentas show normal structure and function in the mouse.

Authors:  A M Herreboudt; V R L Kyle; J Lawrence; J Doran; W H Colledge
Journal:  Placenta       Date:  2014-11-08       Impact factor: 3.481

9.  Kisspeptin modulates sexual and emotional brain processing in humans.

Authors:  Alexander N Comninos; Matthew B Wall; Lysia Demetriou; Amar J Shah; Sophie A Clarke; Shakunthala Narayanaswamy; Alexander Nesbitt; Chioma Izzi-Engbeaya; Julia K Prague; Ali Abbara; Risheka Ratnasabapathy; Victoria Salem; Gurjinder M Nijher; Channa N Jayasena; Mark Tanner; Paul Bassett; Amrish Mehta; Eugenii A Rabiner; Christoph Hönigsperger; Meire Ribeiro Silva; Ole Kristian Brandtzaeg; Elsa Lundanes; Steven Ray Wilson; Rachel C Brown; Sarah A Thomas; Stephen R Bloom; Waljit S Dhillo
Journal:  J Clin Invest       Date:  2017-01-23       Impact factor: 14.808

10.  High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons.

Authors:  Jian Qiu; Casey C Nestor; Chunguang Zhang; Stephanie L Padilla; Richard D Palmiter; Martin J Kelly; Oline K Rønnekleiv
Journal:  Elife       Date:  2016-08-23       Impact factor: 8.140

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  2 in total

1.  Central growth hormone signaling is not required for the timing of puberty.

Authors:  Tabata M Bohlen; Thais T Zampieri; Isadora C Furigo; Pryscila Ds Teixeira; Edward O List; John Kopchick; Jose Donato; Renata Frazao
Journal:  J Endocrinol       Date:  2019-08-01       Impact factor: 4.286

2.  Maternal Engineered Nanomaterial Inhalation During Gestation Disrupts Vascular Kisspeptin Reactivity.

Authors:  Elizabeth C Bowdridge; Alaeddin B Abukabda; Kevin J Engles; Carroll R McBride; Thomas P Batchelor; William T Goldsmith; Krista L Garner; Sherri Friend; Timothy R Nurkiewicz
Journal:  Toxicol Sci       Date:  2019-06-01       Impact factor: 4.849

  2 in total

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