| Literature DB >> 29656135 |
James D Denham1, Dae Hyun Lee2, Manuel Castro3, Shuchi Pandya4, Sadaf Aslam5, Sowmya Nanjappa6, John N Greene7.
Abstract
Vaccines containing live attenuated bacterial or viral organisms are currently being investigated as potential therapy for locally advanced or metastatic cancers. However, the use of such live organisms in an immunocompromised population, such as patients who recently or are currently receiving chemotherapy, raises the concern that these organisms can themselves disseminate and cause frank infection. We report a hereunto unreported phenomenon of anti-cancer vaccines (containing live attenuated organisms) leading to frank, disseminated infection. We submit that occurrence of this phenomenon must be watched for by all members of the interdisciplinary cancer treatment team.Entities:
Keywords: Adenovirus; Anti-cancer vaccine; Listeria monocytogenes; Vaccine-induced disease
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Year: 2018 PMID： 29656135 DOI： 10.1016/j.ijid.2018.04.004
Source DB: PubMed Journal: Int J Infect Dis ISSN： 1201-9712 Impact factor: 3.623