| Literature DB >> 29654887 |
Estefanía Sánchez-Vásquez1, Nagif Alata Jimenez1, Nicolás A Vázquez1, Pablo H Strobl-Mazzulla2.
Abstract
The central dogma of molecular biology statically says that the information flows from DNA to messenger RNA to protein. But the recent advances in mass spectrometry and high throughput technology have helped the scientists to view RNA as little more than a courier of genetic information encoded in the DNA. The dynamics of RNA modifications in coding and non-coding RNAs are just emerging as a carrier of non-genetic information, uncovering a new layer of complexity in the regulation of gene expression and protein translation. In this review, we summarize about the current knowledge of N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C) and pseudouridine (Ψ) modifications in RNA, and described how these RNA modifications are implicated in early animal development and in several human diseases.Entities:
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Year: 2018 PMID： 29654887 DOI： 10.1016/j.mod.2018.04.002
Source DB: PubMed Journal: Mech Dev ISSN： 0925-4773 Impact factor: 1.882