Yixin Bao1, Ruqian He2, Qingyi Zeng2, Pan Zhu2, Rongyuan Zheng2, Huiqin Xu3. 1. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang, China; Department of Neurology, No. 2 Hospital of Jiaxing, Jiaxing 314000, Zhejiang, China. 2. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang, China. 3. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang, China. Electronic address: xuhuiqin1972@163.com.
Abstract
OBJECTIVE: The objective of this study was to apply diffusion tensor imaging (DTI) to investigate microstructural abnormalities in temporal lobe epilepsy (TLE) with and without hippocampal sclerosis (HS). MATERIALS: Totally, 19 patients with TLE with HS and 23 patients with TLE without HS were included. Fiber tracking fibers focused on the parahippocampal cingulum (PHC), cingulate gyrus (CG), and fornix (FORX). Fractional anisotropy (FA) and mean diffusivity (MD) values were obtained, and hippocampal volumes were measured. RESULTS: Compared with the contralateral side, for the HS group, FA values of ipsilateral CG and FORX were significantly decreased, and MD value of ipsilateral hippocampus was significantly higher, with significantly declined ipsilateral hippocampal volume. For the MRI-Neg group, FA values of ipsilateral CG, FORX, and hippocampus were significantly decreased, while MD values of ipsilateral FORX and hippocampus were significantly higher. Moreover, for the MRI-Neg group, the FA value of contralateral PHC was significantly decreased. Fractional anisotropy values of ipsilateral CG for both groups were significantly decreased, and FA value of ipsilateral FORX for the HS group was significantly decreased. Furthermore, MD value of ipsilateral hippocampus for the HS group was significantly higher, and FA value of ipsilateral hippocampus for the MRI-Neg group was significantly decreased. In addition, ipsilateral hippocampal volumes for both groups were significantly decreased. Fractional anisotropy value of ipsilateral CG and FORX had a correlation with the seizure frequency. CONCLUSION: Diffusion tensor imaging can detect microstructural abnormalities in brain from patients with TLE, which might be hard to find with routine Magnetic Resonance Imaging (MRI) sequence.
OBJECTIVE: The objective of this study was to apply diffusion tensor imaging (DTI) to investigate microstructural abnormalities in temporal lobe epilepsy (TLE) with and without hippocampal sclerosis (HS). MATERIALS: Totally, 19 patients with TLE with HS and 23 patients with TLE without HS were included. Fiber tracking fibers focused on the parahippocampal cingulum (PHC), cingulate gyrus (CG), and fornix (FORX). Fractional anisotropy (FA) and mean diffusivity (MD) values were obtained, and hippocampal volumes were measured. RESULTS: Compared with the contralateral side, for the HS group, FA values of ipsilateral CG and FORX were significantly decreased, and MD value of ipsilateral hippocampus was significantly higher, with significantly declined ipsilateral hippocampal volume. For the MRI-Neg group, FA values of ipsilateral CG, FORX, and hippocampus were significantly decreased, while MD values of ipsilateral FORX and hippocampus were significantly higher. Moreover, for the MRI-Neg group, the FA value of contralateral PHC was significantly decreased. Fractional anisotropy values of ipsilateral CG for both groups were significantly decreased, and FA value of ipsilateral FORX for the HS group was significantly decreased. Furthermore, MD value of ipsilateral hippocampus for the HS group was significantly higher, and FA value of ipsilateral hippocampus for the MRI-Neg group was significantly decreased. In addition, ipsilateral hippocampal volumes for both groups were significantly decreased. Fractional anisotropy value of ipsilateral CG and FORX had a correlation with the seizure frequency. CONCLUSION: Diffusion tensor imaging can detect microstructural abnormalities in brain from patients with TLE, which might be hard to find with routine Magnetic Resonance Imaging (MRI) sequence.
Authors: Irena Buksakowska; Nikoletta Szabó; Lukáš Martinkovič; Péter Faragó; András Király; Jiří Vrána; Zsigmond Tamás Kincses; Jan Meluzín; Vlastimil Šulc; Martin Kynčl; Miloslav Roček; Michal Tichý; František Charvát; Daniel Hořínek; Petr Marusič Journal: Front Neurol Date: 2019-10-01 Impact factor: 4.003