Da-Wei Zhang1, Stuart J Johnstone2, Steven Roodenrys3, Xiangsheng Luo4, Hui Li4, Encong Wang5, Qihua Zhao4, Yan Song6, Lu Liu4, Qiujin Qian4, Yufeng Wang4, Li Sun7. 1. School of Psychology, University of Wollongong, Wollongong, NSW, Australia; Brain & Behaviour Research Institute, University of Wollongong, Wollongong, NSW, Australia. 2. School of Psychology, University of Wollongong, Wollongong, NSW, Australia; Brain & Behaviour Research Institute, University of Wollongong, Wollongong, NSW, Australia. Electronic address: sjohnsto@uow.edu.au. 3. School of Psychology, University of Wollongong, Wollongong, NSW, Australia. 4. Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China. 5. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, China; Faculty of Education, Beijing Normal University, Beijing, China. 6. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, China. 7. Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China. Electronic address: sunlioh@bjmu.edu.cn.
Abstract
OBJECTIVE: This study explored the relationships between resting-state electroencephalogram (RS-EEG) localized activation and two important types of executive functions (EF) to extend the prognostic utilization of RS-EEG in children with Attention-Deficit/Hyperactivity Disorder (AD/HD). Also, the role of central nervous system (CNS) arousal in the relationships was examined. METHODS: Fifty-eight children with AD/HD participated in the study. RS-EEG localized activation was derived from spectral power differences between EEG in eyes-closed and eyes-open conditions. CNS arousal was measured based on alpha band power. Common and everyday EF scores were obtained as EF outcomes. RESULTS: Frontal delta activation predicted common EF ability and posterior alpha activation predicted everyday EF. A serial mediation analysis found that lower CNS baseline arousal was related to greater arousal and delta activation in series, which in turn related to worse common EF. A follow-up study found that baseline arousal was related to larger interference cost. CONCLUSIONS: RS-EEG is indicative of individual differences in two important types of EF in children with AD/HD. Lower CNS arousal may be a driving force for the poorer common EF performance. SIGNIFICANCE: The current study supports prognostic utilization of RS-EEG and AD/HD models that take resting brain activity into consideration in children with AD/HD.
OBJECTIVE: This study explored the relationships between resting-state electroencephalogram (RS-EEG) localized activation and two important types of executive functions (EF) to extend the prognostic utilization of RS-EEG in children with Attention-Deficit/Hyperactivity Disorder (AD/HD). Also, the role of central nervous system (CNS) arousal in the relationships was examined. METHODS: Fifty-eight children with AD/HD participated in the study. RS-EEG localized activation was derived from spectral power differences between EEG in eyes-closed and eyes-open conditions. CNS arousal was measured based on alpha band power. Common and everyday EF scores were obtained as EF outcomes. RESULTS: Frontal delta activation predicted common EF ability and posterior alpha activation predicted everyday EF. A serial mediation analysis found that lower CNS baseline arousal was related to greater arousal and delta activation in series, which in turn related to worse common EF. A follow-up study found that baseline arousal was related to larger interference cost. CONCLUSIONS: RS-EEG is indicative of individual differences in two important types of EF in children with AD/HD. Lower CNS arousal may be a driving force for the poorer common EF performance. SIGNIFICANCE: The current study supports prognostic utilization of RS-EEG and AD/HD models that take resting brain activity into consideration in children with AD/HD.
Authors: Rafael Medina; Jaime Bouhaben; Ignacio de Ramón; Pablo Cuesta; Luis Antón-Toro; Javier Pacios; Javier Quintero; Josep Antoni Ramos-Quiroga; Fernando Maestú Journal: J Med Internet Res Date: 2021-11-26 Impact factor: 5.428
Authors: Ignacio de Ramón; Javier Pacios; Rafael Medina; Jaime Bouhaben; Pablo Cuesta; Luis Antón-Toro; Javier Quintero; Antoni Ramos Quiroga; Fernando Maestú Journal: Brain Commun Date: 2022-02-17