| Literature DB >> 29653267 |
Wei Hu1, Zhuo-Yue Bi2, Zhen-Long Chen3, Cong Liu1, Lin-Lin Li1, Feng Zhang1, Qun Zhou1, Wei Zhu1, Yang-Yi-Yan Song1, Bo-Tao Zhan4, Qian Zhang5, Yong-Yi Bi1, Cheng-Cao Sun6, De-Jia Li7.
Abstract
Lung cancer, the leading cause of cancer deaths worldwide, is characterized with malignant cell growth. Advances in next-generation sequencing has helped us further understand RNA and identify novel circular RNAs (circRNAs) that may be useful in the early diagnosis and treatment of lung cancer. Similar to other noncoding RNAs, circRNAs present diverse biological functions in normal and disease states, including various types of cancers. This review focuses mainly on the poorly understood functions of circRNA in lung cancer. This paper also summarizes the recent advances in circRNA biogenesis, analyzes the role of circRNAs in cancers, and discusses the potential mechanisms of circRNAs in lung cancer.Entities:
Keywords: Back-splicing; Biomarker; Circular RNA; Lung cancer; MicroRNA sponge
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Year: 2018 PMID： 29653267 DOI： 10.1016/j.canlet.2018.04.006
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679