Literature DB >> 29653061

To t-Test or Not to t-Test? A p-Values-Based Point of View in the Receiver Operating Characteristic Curve Framework.

Albert Vexler1, Jihnhee Yu1.   

Abstract

A common statistical doctrine supported by many introductory courses and textbooks is that t-test type procedures based on normally distributed data points are anticipated to provide a standard in decision-making. In order to motivate scholars to examine this convention, we introduce a simple approach based on graphical tools of receiver operating characteristic (ROC) curve analysis, a well-established biostatistical methodology. In this context, we propose employing a p-values-based method, taking into account the stochastic nature of p-values. We focus on the modern statistical literature to address the expected p-value (EPV) as a measure of the performance of decision-making rules. During the course of our study, we extend the EPV concept to be considered in terms of the ROC curve technique. This provides expressive evaluations and visualizations of a wide spectrum of testing mechanisms' properties. We show that the conventional power characterization of tests is a partial aspect of the presented EPV/ROC technique. We desire that this explanation of the EPV/ROC approach convinces researchers of the usefulness of the EPV/ROC approach for depicting different characteristics of decision-making procedures, in light of the growing interest regarding correct p-values-based applications.

Keywords:  AUC; ROC curve; Wilcoxon test; expected p-value; p-value; partial AUC; partial expected p-value; power; t-test

Mesh:

Substances:

Year:  2018        PMID: 29653061      PMCID: PMC5998834          DOI: 10.1089/cmb.2017.0216

Source DB:  PubMed          Journal:  J Comput Biol        ISSN: 1066-5277            Impact factor:   1.479


  4 in total

1.  TBARS and cardiovascular disease in a population-based sample.

Authors:  E F Schisterman; D Faraggi; R Browne; J Freudenheim; J Dorn; P Muti; D Armstrong; B Reiser; M Trevisan
Journal:  J Cardiovasc Risk       Date:  2001-08

2.  Minimal and best linear combination of oxidative stress and antioxidant biomarkers to discriminate cardiovascular disease.

Authors:  E F Schisterman; D Faraggi; R Browne; J Freudenheim; J Dorn; P Muti; D Armstrong; B Reiser; M Trevisan
Journal:  Nutr Metab Cardiovasc Dis       Date:  2002-10       Impact factor: 4.222

3.  Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection.

Authors:  Albert Vexler; Aiyi Liu; Ekaterina Eliseeva; Enrique F Schisterman
Journal:  Biometrics       Date:  2007-11-19       Impact factor: 1.701

4.  Expected p-values in light of an ROC curve analysis applied to optimal multiple testing procedures.

Authors:  Albert Vexler; Jihnhee Yu; Yang Zhao; Alan D Hutson; Gregory Gurevich
Journal:  Stat Methods Med Res       Date:  2017-05-15       Impact factor: 2.494

  4 in total

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