Jong Seo Yoon1, Cheol Hwan So2, Hae Sang Lee1, Jin Soon Hwang3. 1. Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Yeongtong-gu, Suwon, Republic of Korea. 2. Department of Pediatrics, Wonkwang University School of Medicine, Wonkwang University Hospital, Iksan, Jeonbuk, Republic of Korea. 3. Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon 443-721, Republic of Korea, Phone: +82-31-219-5166, Fax: +82-31-219-5169.
Abstract
BACKGROUND: The diagnostic cutoff points for indicators of type 2 diabetes mellitus (T2DM) in the pediatric population have not been defined thus far. METHODS: A retrospective, single-center study was conducted from April 2003 to May 2016. We enrolled 236 overweight or obese children and adolescents aged 4-17 years. Thirty-nine (26.9%) of 145 patients had T2DM according to the oral glucose tolerance test results. RESULTS: A glycated hemoglobin (HbA1c) level of 6.5% had a sensitivity and specificity of 87.2% and 98.5%, respectively, for detecting T2DM. The optimal HbA1c cutoff level for T2DM was >6.2% (94.7% sensitivity, 95.5% specificity). CONCLUSIONS: We observed that the use of an HbA1c level of 6.5% had a lower sensitivity for detecting T2DM than an HbA1c level of >6.2%.
BACKGROUND: The diagnostic cutoff points for indicators of type 2 diabetes mellitus (T2DM) in the pediatric population have not been defined thus far. METHODS: A retrospective, single-center study was conducted from April 2003 to May 2016. We enrolled 236 overweight or obesechildren and adolescents aged 4-17 years. Thirty-nine (26.9%) of 145 patients had T2DM according to the oral glucose tolerance test results. RESULTS: A glycated hemoglobin (HbA1c) level of 6.5% had a sensitivity and specificity of 87.2% and 98.5%, respectively, for detecting T2DM. The optimal HbA1c cutoff level for T2DM was >6.2% (94.7% sensitivity, 95.5% specificity). CONCLUSIONS: We observed that the use of an HbA1c level of 6.5% had a lower sensitivity for detecting T2DM than an HbA1c level of >6.2%.
Entities:
Keywords:
HbA1c; obesity; pediatrics; screening; type 2 diabetes