Ji Hyun Lee1, Geun-Tae Kim2, Yun-Kyung Kim3, Seung-Geun Lee4. 1. Division of Rheumatology, Department of Internal Medicine, Maryknoll Medical Center, Busan, Republic of Korea. 2. Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Republic of Korea. gtah@hanmail.net. 3. Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Republic of Korea. 4. Division of Rheumatology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea.
Abstract
OBJECTIVES: Although the relationship between atherosclerosis and cognitive impairment has been studied and replicated, whether cognitive deficits in RA can be attributed to atherosclerotic changes is not well understood. This study investigated cognitive function in patients with RA and evaluated whether cognitive function was affected by carotid arterial atherosclerosis. METHODS: We examined 70 RA patients and 40 healthy controls. RA activity was assessed by disease activity score with 28 joint-erythrocyte sedimentation rate (DAS28-ESR). Cognitive function was assessed by the Korean version of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K) neuropsychological battery. Carotid arteries were scanned for the presence of plaques and to assess intima-media thickness (IMT). We assessed potential risk factors of cognitive impairment in RA patients using regression analyses. RESULTS: There was a significant difference between RA patients and healthy controls in the verbal fluency (p=0.004) and Boston naming test (p=0.035). Carotid ultrasound revealed significantly more plaque in RA patients than in healthy controls (p=0.017). RA patients with memory impairment had significantly higher DAS28-ESR scores (p<0.001), age (p=0.009), and mean cIMT (p=0.027) than RA patients without memory impairment. In multivariable regression analysis, CERAD-K total score showed a significant negative correlation with age (β=-0.415, p<0.001) or DAS28-ESR (β=-4.685, p<0.001), but no correlation was found between CERAD-K total score and presence of plaque or cIMT. CONCLUSIONS: Our results indicate that disease activity of RA and aging contribute to cognitive dysfunction, but there was no association between cognitive function and carotid atherosclerotic changes in RA patients.
OBJECTIVES: Although the relationship between atherosclerosis and cognitive impairment has been studied and replicated, whether cognitive deficits in RA can be attributed to atherosclerotic changes is not well understood. This study investigated cognitive function in patients with RA and evaluated whether cognitive function was affected by carotid arterial atherosclerosis. METHODS: We examined 70 RApatients and 40 healthy controls. RA activity was assessed by disease activity score with 28 joint-erythrocyte sedimentation rate (DAS28-ESR). Cognitive function was assessed by the Korean version of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K) neuropsychological battery. Carotid arteries were scanned for the presence of plaques and to assess intima-media thickness (IMT). We assessed potential risk factors of cognitive impairment in RApatients using regression analyses. RESULTS: There was a significant difference between RApatients and healthy controls in the verbal fluency (p=0.004) and Boston naming test (p=0.035). Carotid ultrasound revealed significantly more plaque in RApatients than in healthy controls (p=0.017). RApatients with memory impairment had significantly higher DAS28-ESR scores (p<0.001), age (p=0.009), and mean cIMT (p=0.027) than RApatients without memory impairment. In multivariable regression analysis, CERAD-K total score showed a significant negative correlation with age (β=-0.415, p<0.001) or DAS28-ESR (β=-4.685, p<0.001), but no correlation was found between CERAD-K total score and presence of plaque or cIMT. CONCLUSIONS: Our results indicate that disease activity of RA and aging contribute to cognitive dysfunction, but there was no association between cognitive function and carotid atherosclerotic changes in RApatients.
Authors: Csaba Oláh; Zsófia Kardos; Mónika Andrejkovics; Enikő Szarka; Katalin Hodosi; Andrea Domján; Mariann Sepsi; Attila Sas; László Kostyál; Katalin Fazekas; Ágnes Flórián; Katalin Lukács; Ágnes Miksi; Zsuzsanna Baráth; György Kerekes; Márta Péntek; Attila Valikovics; László Tamási; Dániel Bereczki; Zoltán Szekanecz Journal: Rheumatol Int Date: 2019-09-25 Impact factor: 2.631
Authors: Nancy A Shadick; Patricia Katz; Christine I Iannaccone; Gabriela Maica; Jonathan Coblyn; Michael E Weinblatt; Jing Cui Journal: ACR Open Rheumatol Date: 2019-10-24
Authors: Natalia Mena-Vázquez; Fernando Ortiz-Márquez; Pablo Cabezudo-García; Claudia Padilla-Leiva; Gisela Diaz-Cordovés Rego; Luis Muñoz-Becerra; Teresa Ramírez-García; Jose Manuel Lisbona-Montañez; Sara Manrique-Arija; Arkaitz Mucientes; Esmeralda Núñez-Cuadros; Rocío Galindo Zavala; Pedro Jesús Serrano-Castro; Antonio Fernández-Nebro Journal: Biomedicines Date: 2022-07-18