| Literature DB >> 29651207 |
Thangarasu Rajakumar1, Pachaiappan Pugalendhi1, Subbaiyan Thilagavathi1.
Abstract
The present study aimed to investigate the protective effect of allyl isothiocyanate (AITC) on glycoprotein components in 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis in female Sprague-Dawley rats. Mammary tumor was induced by a single dose of DMBA (25 mg/rat) injected subcutaneously near mammary gland. The levels of glycoprotein components such as hexose, hexosamine and sialic acid were analyzed colorimetrically in plasma, mammary and liver tissues. We observed an increased levels of glycoprotein components in plasma, mammary and liver tissues in cancer bearing rats. It was further confirmed by Periodic Acid Schiff staining in mammary and liver tissues. Upon oral administration of AITC to DMBA injected rats, the abnormal changes were reverted back to near normal levels and biochemical findings are supported by histological analysis. This could be due to the anti-neoplastic potential of AITC against DMBA-induced mammary carcinogenesis. The result shows that AITC has the potential to inhibit abnormal glycosylation that favors neoplastic transformation.Entities:
Keywords: 7,12-dimethylbenz(a)anthracene; Allyl isothiocyanate; Glycoprotein components; Mammary carcinogenesis
Year: 2017 PMID： 29651207 PMCID： PMC5891455 DOI： 10.1007/s12291-017-0663-4
Source DB: PubMed Journal: Indian J Clin Biochem ISSN： 0970-1915