Shiu Lun Au Yeung1, Maria-Carolina Borges1, Debbie A Lawlor2. 1. School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China (S.L.A.Y.); and MRC Integrative Epidemiology Unit (M.- C.B., D.A.L.) and Population Health Sciences (M.-C.B., D.A.L.), Bristol Medical School, University of Bristol, United Kingdom. 2. School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China (S.L.A.Y.); and MRC Integrative Epidemiology Unit (M.- C.B., D.A.L.) and Population Health Sciences (M.-C.B., D.A.L.), Bristol Medical School, University of Bristol, United Kingdom. d.a.lawlor@bristol.ac.uk.
Abstract
BACKGROUND: Lung function, assessed by forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), is inversely associated with coronary artery disease (CAD), but these associations could be because of confounding or reversed causality. We conducted a 2-sample Mendelian randomization study, using publicly available data from relevant genome-wide association studies, to examine the role of FEV1 or FVC on CAD. METHODS: We used the most recent genome-wide association studies on lung function to extract genetic instruments related to FEV1 and FVC (n=92 749). Data on the association between genetic instruments and CAD were obtained from Coronary Artery Disease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics 1000 Genomes-based genome-wide association studies (60 801 CAD cases and 123 504 controls). We used inverse-variance weighting with a multiplicative random effect to estimate the genetic instrumented association of FEV1 and FVC on CAD. Sensitivity analyses included weighted median and MR-Egger methods. RESULTS: Each SD greater FEV1 was associated with a lower risk of CAD (odds ratio, 0.78 per SD; 95% confidence interval, 0.62-0.98) with a similar magnitude for FVC on CAD risk (odds ratio, 0.82 per SD; 95% confidence interval, 0.64-1.06). Estimates for FEV1 were similar when using MR-Egger method (odds ratio, 0.80 per SD; 95% confidence interval, 0.33-1.94) although the magnitude was smaller for weighted median method (odds ratio, 0.93 per SD; 95% confidence interval, 0.75-1.17). Estimates for FVC in the sensitivity analyses were attenuated (median) or changed direction (MR-Egger). CONCLUSIONS: Our study suggested an inverse relation between FEV1 and CAD, but for FVC, evidence is less clear.
BACKGROUND: Lung function, assessed by forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), is inversely associated with coronary artery disease (CAD), but these associations could be because of confounding or reversed causality. We conducted a 2-sample Mendelian randomization study, using publicly available data from relevant genome-wide association studies, to examine the role of FEV1 or FVC on CAD. METHODS: We used the most recent genome-wide association studies on lung function to extract genetic instruments related to FEV1 and FVC (n=92 749). Data on the association between genetic instruments and CAD were obtained from Coronary Artery Disease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics 1000 Genomes-based genome-wide association studies (60 801 CAD cases and 123 504 controls). We used inverse-variance weighting with a multiplicative random effect to estimate the genetic instrumented association of FEV1 and FVC on CAD. Sensitivity analyses included weighted median and MR-Egger methods. RESULTS: Each SD greater FEV1 was associated with a lower risk of CAD (odds ratio, 0.78 per SD; 95% confidence interval, 0.62-0.98) with a similar magnitude for FVC on CAD risk (odds ratio, 0.82 per SD; 95% confidence interval, 0.64-1.06). Estimates for FEV1 were similar when using MR-Egger method (odds ratio, 0.80 per SD; 95% confidence interval, 0.33-1.94) although the magnitude was smaller for weighted median method (odds ratio, 0.93 per SD; 95% confidence interval, 0.75-1.17). Estimates for FVC in the sensitivity analyses were attenuated (median) or changed direction (MR-Egger). CONCLUSIONS: Our study suggested an inverse relation between FEV1 and CAD, but for FVC, evidence is less clear.
Authors: Baoting He; Man Ki Kwok; Shiu Lun Au Yeung; Shi Lin Lin; June Yue Yan Leung; Lai Ling Hui; Albert M Li; Gabriel M Leung; C Mary Schooling Journal: Sci Rep Date: 2020-01-15 Impact factor: 4.379