Jamie Jarmul1, Mark J Pletcher1, Kristen Hassmiller Lich1, Stephanie B Wheeler1, Morris Weinberger1, Christy L Avery1, Daniel E Jonas1, Stephanie Earnshaw1, Michael Pignone1. 1. Department of Health Policy and Management, Gillings School of Public Health (J.J., K.H.L., S.B.W., M.W.), UNC School of Medicine (J.J., D.E.J.), Department of Epidemiology, Gillings School of Public Health (C.L.A.), Carolina Population Center (C.L.A.), and Cecil G. Sheps Center for Health Services Research (D.E.J.), University of North Carolina-Chapel Hill. Department of Internal Medicine, Dell Medical School, University of Texas-Austin (M.P.). Department of Epidemiology and Biostatistics (M.J.P.) and Department of Medicine (M.J.P.), University of California, San Francisco.
Abstract
BACKGROUND: It is unclear whether testing for novel risk factors, such as a cardiovascular genetic risk score (cGRS), improves clinical decision making or health outcomes when used for targeting statin initiation in the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Our objective was to estimate the cost-effectiveness of cGRS testing to inform clinical decision making about statin initiation in individuals with low-to-intermediate (2.5%-7.5%) 10-year predicted risk of ASCVD. METHODS AND RESULTS: We evaluated the cost-effectiveness of testing for a 27-single-nucleotide polymorphism cGRS comparing 4 test/treat strategies: treat all, treat none, test/treat if cGRS is high, and test/treat if cGRS is intermediate or high. We tested a set of clinical scenarios of men and women, aged 45 to 65 years, with 10-year ASCVD risks between 2.5% and 7.5%. Our primary outcome measure was cost per quality-adjusted life-year gained. Under base case assumptions for statin disutility and cost, the preferred strategy is to treat all patients with ASCVD risk >2.5% without cGRS testing. For certain clinical scenarios, such as a 57-year-old man with a 10-year ASCVD risk of 7.5%, cGRS testing can be cost-effective under a limited set of assumptions; for example, when statins cost $15 per month and statin disutility is 0.013 (ie, willing to trade 3 months of life in perfect health to avoid 20 years of statin therapy), the preferred strategy (using a willingness-to-pay threshold of $50 000 per quality-adjusted life-year gained) is to test and treat if cGRS is intermediate or high. Overall, the results were not sensitive to assumptions about statin efficacy and harms. CONCLUSIONS: Testing for a 27-single-nucleotide polymorphism cGRS is generally not a cost-effective approach for targeting statin therapy in the primary prevention of ASCVD for low- to intermediate-risk patients.
BACKGROUND: It is unclear whether testing for novel risk factors, such as a cardiovascular genetic risk score (cGRS), improves clinical decision making or health outcomes when used for targeting statin initiation in the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Our objective was to estimate the cost-effectiveness of cGRS testing to inform clinical decision making about statin initiation in individuals with low-to-intermediate (2.5%-7.5%) 10-year predicted risk of ASCVD. METHODS AND RESULTS: We evaluated the cost-effectiveness of testing for a 27-single-nucleotide polymorphism cGRS comparing 4 test/treat strategies: treat all, treat none, test/treat if cGRS is high, and test/treat if cGRS is intermediate or high. We tested a set of clinical scenarios of men and women, aged 45 to 65 years, with 10-year ASCVD risks between 2.5% and 7.5%. Our primary outcome measure was cost per quality-adjusted life-year gained. Under base case assumptions for statin disutility and cost, the preferred strategy is to treat all patients with ASCVD risk >2.5% without cGRS testing. For certain clinical scenarios, such as a 57-year-old man with a 10-year ASCVD risk of 7.5%, cGRS testing can be cost-effective under a limited set of assumptions; for example, when statins cost $15 per month and statin disutility is 0.013 (ie, willing to trade 3 months of life in perfect health to avoid 20 years of statin therapy), the preferred strategy (using a willingness-to-pay threshold of $50 000 per quality-adjusted life-year gained) is to test and treat if cGRS is intermediate or high. Overall, the results were not sensitive to assumptions about statin efficacy and harms. CONCLUSIONS: Testing for a 27-single-nucleotide polymorphism cGRS is generally not a cost-effective approach for targeting statin therapy in the primary prevention of ASCVD for low- to intermediate-risk patients.
Authors: Deo Mujwara; Geoffrey Henno; Stephen T Vernon; Siyang Peng; Paolo Di Domenico; Brock Schroeder; George B Busby; Gemma A Figtree; Giordano Bottà Journal: J Am Heart Assoc Date: 2022-06-14 Impact factor: 6.106
Authors: Jerry Zeng Yang Wong; Jia Hui Chai; Yen Shing Yeoh; Nur Khaliesah Mohamed Riza; Jenny Liu; Yik-Ying Teo; Hwee Lin Wee; Mikael Hartman Journal: BMC Health Serv Res Date: 2021-04-23 Impact factor: 2.655
Authors: Ankur Pandya; David A Asch; Kevin G Volpp; Stephen Sy; Andrea B Troxel; Jingsan Zhu; Milton C Weinstein; Meredith B Rosenthal; Thomas A Gaziano Journal: JAMA Netw Open Date: 2018-09-07