| Literature DB >> 29650672 |
Craig B Wilen1, Sanghyun Lee1, Leon L Hsieh1, Robert C Orchard1, Chandni Desai1, Barry L Hykes1, Michael R McAllaster1, Dale R Balce1, Taylor Feehley1, Jonathan R Brestoff1, Christina A Hickey1, Christine C Yokoyama1, Ya-Ting Wang1, Donna A MacDuff2, Darren Kreamalmayer1, Michael R Howitt3, Jessica A Neil4, Ken Cadwell4, Paul M Allen1, Scott A Handley1, Menno van Lookeren Campagne5, Megan T Baldridge6, Herbert W Virgin7.
Abstract
Complex interactions between host immunity and the microbiome regulate norovirus infection. However, the mechanism of host immune promotion of enteric virus infection remains obscure. The cellular tropism of noroviruses is also unknown. Recently, we identified CD300lf as a murine norovirus (MNoV) receptor. In this study, we have shown that tuft cells, a rare type of intestinal epithelial cell, express CD300lf and are the target cell for MNoV in the mouse intestine. We found that type 2 cytokines, which induce tuft cell proliferation, promote MNoV infection in vivo. These cytokines can replace the effect of commensal microbiota in promoting virus infection. Our work thus provides insight into how the immune system and microbes can coordinately promote enteric viral infection.Entities:
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Year: 2018 PMID： 29650672 PMCID： PMC6039974 DOI： 10.1126/science.aar3799
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728