Alejandro Avila-Alvarez1, Alfonso Solar Boga2, Carmen Bermúdez-Hormigo3, Jesús Fuentes Carballal4. 1. Unidad de Neonatología, Servicio de Pediatría. Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, España; Departamento de Pediatría, Universidade de Santiago de Compostela, Santiago de Compostela, España. Electronic address: alejandro.avila.neonatologia@gmail.com. 2. Unidad de Gastroenterología, Hepatología y Nutrición pediátrica, Servicio de Pediatría, Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, España; Departamento de Pediatría, Universidade de Santiago de Compostela, Santiago de Compostela, España. 3. Unidad de Neonatología, Servicio de Pediatría. Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, España; Departamento de Pediatría, Universidade de Santiago de Compostela, Santiago de Compostela, España. 4. Unidad de Neonatología, Servicio de Pediatría. Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, España.
Abstract
INTRODUCTION: Growth restriction in preterm infants has been related to a poor neurodevelopment outcome. OBJECTIVES: To define the incidence of postnatal growth restriction in premature babies ≤1,500 grams and to detect related clinical or biochemical markers. METHODS: Retrospective longitudinal observational study. Multivariate linear regression models were used to determine variables that can predict the change in weight z-score during admission. RESULTS: The study included 130 patients with a mean birthweight of 1,161±251grams and a gestational age of 29.9±2.5 weeks. At hospital discharge, 59.2% had a weight below P10.During admission, the z-scores of weight and length decreased by -0.85±0.79 and -1.09±0.65, respectively.The largest decrease in z-score occurred during NICU admission, with a weight gain rate of 6.6±8.8g/Kg/day, after which growth acceleration took place (16.7±3.8g/Kg/day), but was insufficient to catch-up.Higher levels of urea were negatively correlated with the change in the z-score of weight (P<.001), and a weight <P10 at birth positively correlated (P=.013). CONCLUSIONS: More than half of newborns ≤1,500 grams have a weight at discharge of <P10. This growth restriction occurs during NICU admission, and affects low birth weight infants less frequently.Urea levels correlate negatively with weight gain, which requires further study of the relationship between growth and the protein compartment.
INTRODUCTION: Growth restriction in preterm infants has been related to a poor neurodevelopment outcome. OBJECTIVES: To define the incidence of postnatal growth restriction in premature babies ≤1,500 grams and to detect related clinical or biochemical markers. METHODS: Retrospective longitudinal observational study. Multivariate linear regression models were used to determine variables that can predict the change in weight z-score during admission. RESULTS: The study included 130 patients with a mean birthweight of 1,161±251grams and a gestational age of 29.9±2.5 weeks. At hospital discharge, 59.2% had a weight below P10.During admission, the z-scores of weight and length decreased by -0.85±0.79 and -1.09±0.65, respectively.The largest decrease in z-score occurred during NICU admission, with a weight gain rate of 6.6±8.8g/Kg/day, after which growth acceleration took place (16.7±3.8g/Kg/day), but was insufficient to catch-up.Higher levels of urea were negatively correlated with the change in the z-score of weight (P<.001), and a weight <P10 at birth positively correlated (P=.013). CONCLUSIONS: More than half of newborns ≤1,500 grams have a weight at discharge of <P10. This growth restriction occurs during NICU admission, and affects low birth weight infants less frequently.Urea levels correlate negatively with weight gain, which requires further study of the relationship between growth and the protein compartment.
Authors: Juliany Caroline Silva de Sousa; Ana Verônica Dantas de Carvalho; Lorena de Carvalho Monte de Prada; Arthur Pedro Marinho; Kerolaynne Fonseca de Lima; Suianny Karla de Oliveira Macedo; Camila Dayze Pereira Santos; Saionara Maria Aires da Câmara; Anna Christina do Nascimento Granjeiro Barreto; Silvana Alves Pereira Journal: Nutrients Date: 2021-12-31 Impact factor: 5.717
Authors: Ana María Sánchez-García; Ana Zaragoza-Martí; Ana Cristina Murcia-López; Andrés Navarro-Ruiz; Ana Noreña-Peña Journal: Int J Environ Res Public Health Date: 2020-03-23 Impact factor: 3.390