Literature DB >> 2965027

Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin.

J R Wright1, J Mendola, P E Lacy.   

Abstract

Weanling CD-1 mice were fed either a control diet or a diet deficient in niacin/nicotinamide for one month and then injected i.v. with 60, 80, 100, 120, 140, or 160 mg/kg streptozotocin. Mice on the deficient diet developed a higher incidence of diabetes and more severe hyperglycemia than those on the control diet.

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Year:  1988        PMID： 2965027     DOI： 10.1007/bf01960237

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  The role of poly(ADP-ribose) synthetase in the development of insulin-dependent diabetes and islet B-cell regeneration.

Authors:  H Okamoto
Journal:  Biomed Biochim Acta       Date:  1985

2.  Pyridine nucleotide depletion in pancreatic islets associated with streptozotocin-induced diabetes.

Authors:  C K Ho; S A Hashim
Journal:  Diabetes       Date:  1972-07       Impact factor: 9.461

3.  Reversal of streptozotocin diabetes with nicotinamide.

Authors:  W E Dulin; B M Wyse
Journal:  Proc Soc Exp Biol Med       Date:  1969-03

4.  The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity.

Authors:  P S Schein; D A Cooney; M L Vernon
Journal:  Cancer Res       Date:  1967-12       Impact factor: 12.701

5.  Streptozotocin diabetes: time course of irreversible B-cell damage; further observations on prevention by nicotinamide.

Authors:  W Stauffacher; I Burr; A Gutzeit; D Beaven; J Veleminsky; A E Renold
Journal:  Proc Soc Exp Biol Med       Date:  1970-01

Review 6.  Drugs producing diabetes through damage of the insulin secreting cells.

Authors:  C C Rerup
Journal:  Pharmacol Rev       Date:  1970-12       Impact factor: 25.468

7.  Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis.

Authors:  Y Uchigata; H Yamamoto; A Kawamura; H Okamoto
Journal:  J Biol Chem       Date:  1982-06-10       Impact factor: 5.157

8.  Influence of nicotinamide and pyridine nucleotides on streptozotocin and alloxan-induced pancreatic B cell cytotoxicity.

Authors:  S S Lazarus; S H Shapiro
Journal:  Diabetes       Date:  1973-07       Impact factor: 9.461

9.  Effects of streptozotocin on a clonal isolate of rat insulinoma cells.

Authors:  S P Ledoux; G L Wilson
Journal:  Biochim Biophys Acta       Date:  1984-08-17

10.  Streptozotocin diabetes. Correlation with extent of depression of pancreatic islet nicotinamide adenine dinucleotide.

Authors:  T Anderson; P S Schein; M G McMenamin; D A Cooney
Journal:  J Clin Invest       Date:  1974-09       Impact factor: 14.808
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  2 in total

1.  Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.

Authors:  M Sulaiman; M J Matta; N R Sunderesan; M P Gupta; M Periasamy; M Gupta
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-12-11       Impact factor: 4.733

2.  Absence of a reductase, NCB5OR, causes insulin-deficient diabetes.

Authors:  Jianxin Xie; Hao Zhu; Kevin Larade; Annie Ladoux; Ayden Seguritan; Michelle Chu; Susumu Ito; Roderick T Bronson; Edward H Leiter; Chen-Yu Zhang; Evan D Rosen; H Franklin Bunn
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-09       Impact factor: 11.205
  2 in total

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