Yu-Cheng Lai1, Chun-Yeh Wang1, Sin-Hua Moi2, Chien-Hsing Wu1, Cheng-Hong Yang2, Jin-Bor Chen1. 1. Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. 2. Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan.
Abstract
BACKGROUND/AIMS: We investigated factors associated with functional performance in hemodialysis (HD) patients as well as their relationships with mortality. METHODS: We enrolled 790 HD patients who were followed up from 2009 to 2013. Functional performance was evaluated by Karnofsky Performance Status Scale (KPSS) scores. We examined the associations of clinical variables and all-cause mortality with KPSS scores. RESULTS: Of the participants, 460 had high KPSS scores (range 90-100) and 330 had low KPSS scores (below 80). On multivariate analysis, age and weekly HD sessions were associated with significantly increased odds of a lower KPSS score (age: OR 1.05, 95% CI 1.04-1.07, p < 0.001; weekly HD: OR 2.10, 95% CI 1.37-3.21, p = 0.001). A low KPSS score was a significant predictor of increased all-cause mortality (hazard ratio 1.49; 95% CI 1.02-2.16, p = 0.037), as determined using Cox regression analysis. CONCLUSION: Functional performance was associated with clinical variables and all-cause mortality in HD patients.
BACKGROUND/AIMS: We investigated factors associated with functional performance in hemodialysis (HD) patients as well as their relationships with mortality. METHODS: We enrolled 790 HDpatients who were followed up from 2009 to 2013. Functional performance was evaluated by Karnofsky Performance Status Scale (KPSS) scores. We examined the associations of clinical variables and all-cause mortality with KPSS scores. RESULTS: Of the participants, 460 had high KPSS scores (range 90-100) and 330 had low KPSS scores (below 80). On multivariate analysis, age and weekly HD sessions were associated with significantly increased odds of a lower KPSS score (age: OR 1.05, 95% CI 1.04-1.07, p < 0.001; weekly HD: OR 2.10, 95% CI 1.37-3.21, p = 0.001). A low KPSS score was a significant predictor of increased all-cause mortality (hazard ratio 1.49; 95% CI 1.02-2.16, p = 0.037), as determined using Cox regression analysis. CONCLUSION: Functional performance was associated with clinical variables and all-cause mortality in HDpatients.
Authors: Wen-Sheng Liu; Hsiang Lin Chan; Yen-Ting Lai; Chih-Ching Lin; Szu-Yuan Li; Chih-Kuang Liu; Han-Hsing Tsou; Tsung-Yun Liu Journal: Int J Environ Res Public Health Date: 2018-11-17 Impact factor: 3.390