Yoav Michowitz1, Anat Milman1, Georgia Sarquella-Brugada2, Antoine Andorin3, Jean Champagne4, Pieter G Postema5, Ruben Casado-Arroyo6, Eran Leshem7, Jimmy J M Juang8, Carla Giustetto9, Jacob Tfelt-Hansen10, Yanushi D Wijeyeratne11, Christian Veltmann12, Domenico Corrado13, Sung-Hwan Kim14, Pietro Delise15, Shingo Maeda16, Jean-Baptiste Gourraud3, Frederic Sacher17, Philippe Mabo18, Yoshihide Takahashi16, Tsukasa Kamakura19, Takeshi Aiba19, Giulio Conte20, Aviram Hochstadt21, Yuka Mizusawa5, Michael Rahkovich22, Elena Arbelo23, Zhengrong Huang24, Isabelle Denjoy25, Carlo Napolitano26, Ramon Brugada27, Leonardo Calo28, Silvia G Priori26, Masahiko Takagi29, Elijah R Behr30, Fiorenzo Gaita9, Gan-Xin Yan31, Josep Brugada23, Antoine Leenhardt25, Arthur A M Wilde5, Pedro Brugada32, Kengo F Kusano19, Kenzo Hirao16, Gi-Byoung Nam33, Vincent Probst3, Bernard Belhassen34. 1. Department of Cardiology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 2. European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart); Pediatric Arrhythmias, Electrophysiology and Sudden Death Unit, Cardiology Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain. 3. European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart); L'institut du Thorax, Service de Cardiologie, CHU de Nantes, Nantes, France. 4. Quebec Heart and Lung Institute, Quebec City, Quebec, Canada. 5. European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart); Heart Centre AMC, Department of Clinical and Experimental Cardiology, AMC, University of Amsterdam, Amsterdam, The Netherlands. 6. Department of Cardiology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. 7. Department of Cardiology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Beth Israel Deaconess Medical Center, Boston, Massachusetts. 8. Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. 9. Division of Cardiology, University of Torino, Department of Medical Sciences, Città della Salute e della Scienza Hospital, Torino, Italy. 10. European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart); Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 11. Cardiovascular Sciences, St. George's University of London and Cardiology Clinical Academic Group St. George's University Hospitals NHS Foundation Trust, London, United Kingdom. 12. Division of Rhythmology and Electrophysiology, Department of Cardiology, Hannover Medical School, Hannover, Germany. 13. European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy. 14. Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. 15. Division of Cardiology, Hospital of Peschiera del Garda, Veneto, Italy. 16. Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan. 17. Hôpital Cardiologique du Haut-Lévêque & Université Bordeaux, LIRYC Institute, Bordeaux, France. 18. Cardiology and Vascular Disease Division, Rennes University Health Centre, Rennes, France. 19. Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan. 20. Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium. 21. Department of Internal Medicine J, Tel Aviv Medical Center, Tel Aviv, Israel. 22. Department of Cardiology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Arrhythmia Services, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. 23. Cardiology Department, Cardiovascular Institute, Hospital Clinic and IDIBAPS, Barcelona, Spain. 24. Department of Cardiology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China. 25. European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart); Service de Cardiologie et CNMR Maladies Cardiaques Héréditaires Rares, Hôpital Bichat, Paris, France, and Université Paris Diderot, Paris, France. 26. European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart); Molecular Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy. 27. Cardiovascular Genetics Center, University of Girona-IDIBGI, Girona, Spain; Medical Science Department, School of Medicine, University of Girona, Girona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. 28. Division of Cardiology, Policlinico Casilino, Roma, Italy. 29. Division of Cardiac Arrhythmia, Kansai Medical University Medical Center, Moriguchi, Japan. 30. European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart); Cardiovascular Sciences, St. George's University of London and Cardiology Clinical Academic Group St. George's University Hospitals NHS Foundation Trust, London, United Kingdom. 31. Lankenau Medical Center, Wynnewood, Pennsylvania. 32. European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart); Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium. 33. Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 34. Department of Cardiology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: bblhass@gmail.com.
Abstract
BACKGROUND: The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. OBJECTIVE: The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. METHODS: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). RESULTS: In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3-76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0-5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. CONCLUSION: The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.
BACKGROUND: The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. OBJECTIVE: The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. METHODS: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). RESULTS: In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3-76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0-5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. CONCLUSION: The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.
Authors: Martin K Stiles; Arthur A M Wilde; Dominic J Abrams; Michael J Ackerman; Christine M Albert; Elijah R Behr; Sumeet S Chugh; Martina C Cornel; Karen Gardner; Jodie Ingles; Cynthia A James; Jyh-Ming Jimmy Juang; Stefan Kääb; Elizabeth S Kaufman; Andrew D Krahn; Steven A Lubitz; Heather MacLeod; Carlos A Morillo; Koonlawee Nademanee; Vincent Probst; Elizabeth V Saarel; Luciana Sacilotto; Christopher Semsarian; Mary N Sheppard; Wataru Shimizu; Jonathan R Skinner; Jacob Tfelt-Hansen; Dao Wu Wang Journal: Heart Rhythm Date: 2020-10-19 Impact factor: 6.343
Authors: Peter J Schwartz; Michael J Ackerman; Charles Antzelevitch; Connie R Bezzina; Martin Borggrefe; Bettina F Cuneo; Arthur A M Wilde Journal: Nat Rev Dis Primers Date: 2020-07-16 Impact factor: 52.329
Authors: Martin K Stiles; Arthur A M Wilde; Dominic J Abrams; Michael J Ackerman; Christine M Albert; Elijah R Behr; Sumeet S Chugh; Martina C Cornel; Karen Gardner; Jodie Ingles; Cynthia A James; Jyh-Ming Jimmy Juang; Stefan Kääb; Elizabeth S Kaufman; Andrew D Krahn; Steven A Lubitz; Heather MacLeod; Carlos A Morillo; Koonlawee Nademanee; Vincent Probst; Elizabeth V Saarel; Luciana Sacilotto; Christopher Semsarian; Mary N Sheppard; Wataru Shimizu; Jonathan R Skinner; Jacob Tfelt-Hansen; Dao Wu Wang Journal: J Arrhythm Date: 2021-04-08
Authors: Humberto Rodriguez-Reyes; Andrés Pérez-Riera; Brenda Lucia López; Maria Del Refugio Salinas; Luz Ma Mayela Muñoz; Cesar Ivan Laguna; Nikus Kjell Journal: Ann Noninvasive Electrocardiol Date: 2019-09-30 Impact factor: 1.468
Authors: Jennifer Carron; Zain Sharif; Hafiz Hussein; Mark Kennedy; Brendan McAdam; Richard Sheahan Journal: Ir J Med Sci Date: 2020-07-06 Impact factor: 1.568