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Literature DB >> 2964960

The expression of CD18 is increased on Trisomy 21 (Down syndrome) lymphoblastoid cells.

G M Taylor¹, A Williams, S W D'Souza, W D Fergusson, D Donnai, J Fennell, R Harris.

Abstract

The monoclonal antibody (MAB) 60.3 reacts with the beta chain (CD18) of lymphocyte function associated antigen (LFA-1), encoded by a gene on chromosome 21. We have used 60.3 to measure the expression of CD18 on lymphoblastoid cell-lines derived from persons with Trisomy 21 (Down syndrome) by quantitative fluorescence flow cytometric analysis. This showed that CD18 expression is increased on Trisomy 21 compared with normal cells, whereas neither HLA-class I, nor transferrin receptor expression are significantly affected. Similar results were obtained with the CD18 MAB MHM 23, and with the CD11a MAB MHM 24 (LFA-1 alpha). These results suggest that the increase in CD18 expression by Trisomy 21 cells is due to gene dosage, and could influence the immune status of persons with Down syndrome.

Entities: Gene Species

Mesh：

Substances：

Year: 1988 PMID： 2964960 PMCID： PMC1541443

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

18 in total

1. Definition of a common leukocyte cell-surface antigen (Lp95-150) associated with diverse cell-mediated immune functions.

Authors: P G Beatty; J A Ledbetter; P J Martin; T H Price; J A Hansen
Journal: J Immunol Date: 1983-12 Impact factor: 5.422

2. Genetic and biochemical characterization of a human surface determinant on somatic cell hybrids: the 4F2 antigen.

Authors: P G Peters; M E Kamarck; M E Hemler; J L Strominger; F H Ruddle
Journal: Somatic Cell Genet Date: 1982-11

3. Longevity and mortality in Down's syndrome.

Authors: M E Thase
Journal: J Ment Defic Res Date: 1982-09

4. Gene dosage and gene expression in the HLA region: evidence from deletion variants.

Authors: P Gladstone; L Fueresz; D Pious
Journal: Proc Natl Acad Sci U S A Date: 1982-02 Impact factor: 11.205

5. The beta2-microglobulin gene is on chromosome 15 and not in the HL-A region.

Authors: P N Goodfellow; E A Jones; V Van Heyningen; E Solomon; M Bobrow; V Miggiano; W F Bodmer
Journal: Nature Date: 1975-03-20 Impact factor: 49.962

6. Expression of human transferrin receptor is controlled by a gene on chromosome 3: assignment using species specificity of a monoclonal antibody.

Authors: P N Goodfellow; G Banting; R Sutherland; M Greaves; E Solomon; S Povey
Journal: Somatic Cell Genet Date: 1982-03

7. Thymic deficiency in Down's syndrome.

Authors: S Levin; M Schlesinger; Z Handzel; T Hahn; Y Altman; B Czernobilsky; J Boss
Journal: Pediatrics Date: 1979-01 Impact factor: 7.124

8. Human lymphocyte function associated antigen-1 (LFA-1): identification of multiple antigenic epitopes and their relationship to CTL-mediated cytotoxicity.

Authors: C F Ware; F Sanchez-Madrid; A M Krensky; S J Burakoff; J L Strominger; T A Springer
Journal: J Immunol Date: 1983-09 Impact factor: 5.422

9. A human lymphocyte-associated antigen involved in cell-mediated lympholysis.

Authors: J E Hildreth; F M Gotch; P D Hildreth; A J McMichael
Journal: Eur J Immunol Date: 1983-03 Impact factor: 5.532

10. A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

Authors: F Sanchez-Madrid; J A Nagy; E Robbins; P Simon; T A Springer
Journal: J Exp Med Date: 1983-12-01 Impact factor: 14.307

8 in total

1. Differential expression of lymphocyte function-associated antigen (LFA-1) on peripheral blood leucocytes from individuals with Down's syndrome.

Authors: M J Barrena; P Echaniz; C Garcia-Serrano; P Zubillaga; E Cuadrado
Journal: Clin Exp Immunol Date: 1992-04 Impact factor: 4.330

2. Analysis of gene-dosage effects on the expression of CD18 by trisomy 21 lymphoblastoid cell-lines using a statistical model to fit flow cytometry profiles.

Authors: W G Bardsley; B P McMurray; A Robson; S D'Souza; G M Taylor
Journal: Hum Genet Date: 1990-12 Impact factor: 4.132

3. A unique downregulation of h2-calponin gene expression in Down syndrome: a possible attenuation mechanism for fetal survival by methylation at the CpG island in the trisomic chromosome 21.

Authors: J Kuromitsu; H Yamashita; H Kataoka; T Takahara; M Muramatsu; T Sekine; N Okamoto; Y Furuichi; Y Hayashizaki
Journal: Mol Cell Biol Date: 1997-02 Impact factor: 4.272

4. Down's syndrome lymphoid cell lines exhibit increased adhesion due to the over-expression of lymphocyte function-associated antigen (LFA-1).

Authors: G M Taylor; H Haigh; A Williams; S W D'Souza; R Harris
Journal: Immunology Date: 1988-07 Impact factor: 7.397