Birgith Pedersen1, Charlotte Delmar, Tamás Lörincz, Ursula Falkmer, Mette Grønkjær. 1. Author Affiliations: Department of Oncology and Clinical Cancer Research Center (Drs Pedersen, Lörincz, and Falkmer); Clinical Nursing Research Unit (Drs Pedersen and Grønkjær), Aalborg University Hospital; Department of Clinical Medicine, Aalborg University (Drs Falkmer and Grønkjær); Institute of Public Health, Section of Nursing, Aarhus University and Health Faculty, Aalborg University, Denmark (Dr Delmar); University College Diakonova, Oslo (Dr Delmar); and The Arctic University of Norway Tromsø, Norway (Dr Delmar).
Abstract
BACKGROUND: Despite several investigations, findings on weight changes during and after adjuvant treatment for breast cancer are diverse and point in several directions. OBJECTIVE: The aims of this study were to investigate changes in weight and body composition associated with contemporary anticancer medication and to examine factors that might influence the assessment and diversity of the findings. METHODS: This article used the method of a scoping review to map the body of literature. From searching the databases PubMed, CINAHL, and EMBASE using MeSH terms, CINAHL terms, and Emtree, as well as free text, 19 articles were selected for further investigation. RESULTS: The scoping review illustrates how findings in weight and body composition changes fluctuate over time as illustrated in 4 measure points: short term, 1 year, 18 months/2 years, and long term. The studies displayed differences regarding study designs, sample sizes, treatment regimens, measure points and techniques, and cutoff values for assessing weight changes, which make it difficult to synthesize findings and provide strong evidence for use in clinical practice. CONCLUSION: Synthesizing findings over time illustrates the need for attention on younger premenopausal women given chemotherapy. Weight need to be monitored for at least 2 years as short-term changes may be caused by increased body water, whereas long-term changes seem to be related with increased fat mass essential for risking recurrence and early death. IMPLICATIONS FOR PRACTICE: The diversity in methods discloses the need for the research community to reach consensus regarding study designs for future research in this area.
BACKGROUND: Despite several investigations, findings on weight changes during and after adjuvant treatment for breast cancer are diverse and point in several directions. OBJECTIVE: The aims of this study were to investigate changes in weight and body composition associated with contemporary anticancer medication and to examine factors that might influence the assessment and diversity of the findings. METHODS: This article used the method of a scoping review to map the body of literature. From searching the databases PubMed, CINAHL, and EMBASE using MeSH terms, CINAHL terms, and Emtree, as well as free text, 19 articles were selected for further investigation. RESULTS: The scoping review illustrates how findings in weight and body composition changes fluctuate over time as illustrated in 4 measure points: short term, 1 year, 18 months/2 years, and long term. The studies displayed differences regarding study designs, sample sizes, treatment regimens, measure points and techniques, and cutoff values for assessing weight changes, which make it difficult to synthesize findings and provide strong evidence for use in clinical practice. CONCLUSION: Synthesizing findings over time illustrates the need for attention on younger premenopausal women given chemotherapy. Weight need to be monitored for at least 2 years as short-term changes may be caused by increased body water, whereas long-term changes seem to be related with increased fat mass essential for risking recurrence and early death. IMPLICATIONS FOR PRACTICE: The diversity in methods discloses the need for the research community to reach consensus regarding study designs for future research in this area.
Authors: Michelle Harvie; Mary Pegington; Sacha J Howell; Nigel Bundred; Phil Foden; Judith Adams; Lee Graves; Alastair Greystoke; Mark P Mattson; Roy G Cutler; Julie Williamson; Karen Livingstone; Debbie McMullen; Katharine Sellers; Cheryl Lombardelli; Grace Cooper; Sarah McDiarmid; Anthony Howell Journal: Br J Cancer Date: 2021-12-15 Impact factor: 9.075
Authors: Bo Qin; Kate Kim; Noreen Goldman; Andrew G Rundle; Dhanya Chanumolu; Nur Zeinomar; Baichen Xu; Karen S Pawlish; Christine B Ambrosone; Kitaw Demissie; Chi-Chen Hong; Gina S Lovasi; Elisa V Bandera Journal: J Clin Oncol Date: 2022-03-25 Impact factor: 50.717