Literature DB >> 2964820

Paradoxical stimulation of both lipocortin and prostaglandin production in human amnion cells by dexamethasone.

M D Mitchell1, F D Lytton, L Varticovski.   

Abstract

Glucocorticoids inhibit prostaglandin biosynthesis by inducing the formation of lipocortins. In human amnion cells dexamethasone elicited a concentration-dependent increase in prostaglandin production and raised intracellular lipocortin 1 concentrations. Dexamethasone could also potentiate the epidermal growth factor (EGF)-induced stimulation of prostaglandin production. EGF alone or in combination with dexamethasone increased lipocortin 1 formation in amnion cells. Human amnion cells may provide a unique insight into interactions between glucocorticoids, lipocortin and eicosanoid biosynthesis.

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Year:  1988        PMID： 2964820     DOI： 10.1016/0006-291x(88)90569-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Inhaled budesonide regimen enhances serotonin- and arachidonic acid-induced platelet aggregation.

Authors:  L Hasselmark; R Malmgren; A Dumitrescu
Journal:  Agents Actions       Date:  1992-05

2.  Decreased inhibition by gravidin of arachidonate release from transformed compared to nontransformed cells.

Authors:  T Wilson; R K Ralph; R Ganendren
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

3.  Biphasic regulation by dexamethasone of IL-1- and LPS-stimulated endothelial prostacyclin production.

Authors:  G Prajgrod; A Danon
Journal:  Agents Actions       Date:  1992-03

4.  Glucocorticoid-and non-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leucocytes in vivo.

Authors:  S H Peers; F Smillie; A J Elderfield; R J Flower
Journal:  Br J Pharmacol       Date:  1993-01       Impact factor: 8.739

5.  Biphasic regulation by dexamethasone of IL-1- and LPS-stimulated endothelial prostacyclin production.

Authors:  G Prajgrod; A Danon
Journal:  Agents Actions       Date:  1992-05

6.  The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes.

Authors:  R Huber; J Römisch; E P Paques
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598

7.  C/EBPδ drives key endocrine signals in the human amnion at parturition.

Authors:  Jiang-Wen Lu; Wang-Sheng Wang; Qiong Zhou; Li-Jun Ling; Hao Ying; Yun Sun; Leslie Myatt; Kang Sun
Journal:  Clin Transl Med       Date:  2021-06
  7 in total

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