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Literature DB >> 2964637

Suppression of contractile force in muscle fibers by antibody to myosin subfragment 2.

Abstract

Polyclonal antibody directed against the subfragment-2 region of myosin was purified by affinity chromatography. Skinned muscle fibers that had been preincubated with antibody were able to sustain only 7% of the active isometric force generated by control fibers. The effect of antibody on force production could not be accounted for by inhibition of ATP turnover.

Entities: Chemical Gene

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Year: 1988 PMID： 2964637 PMCID： PMC279878 DOI： 10.1073/pnas.85.6.1849

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

Review 1. Structure of muscle filaments from immunohistochemical and ultrastructural studies.

Authors: F A Pepe
Journal: J Histochem Cytochem Date: 1975-07 Impact factor: 2.479

2. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.

Authors: R R PORTER
Journal: Biochem J Date: 1959-09 Impact factor: 3.857

Review 3. Crossbridge behaviour during muscle contraction.

Authors: H E Huxley; M Kress
Journal: J Muscle Res Cell Motil Date: 1985-04 Impact factor: 2.698

4. On the origin of the contractile force in skeletal muscle.

Authors: W F Harrington
Journal: Proc Natl Acad Sci U S A Date: 1979-10 Impact factor: 11.205

Review 5. The mechanism of muscular contraction.

Authors: H E Huxley
Journal: Science Date: 1969-06-20 Impact factor: 47.728

6. Proposed mechanism of force generation in striated muscle.

Authors: A F Huxley; R M Simmons
Journal: Nature Date: 1971-10-22 Impact factor: 49.962

7. Tonicity effects on intact single muscle fibers: relation between force and cell volume.

Authors: J Gulati; A Babu
Journal: Science Date: 1982-02-26 Impact factor: 47.728

8. Isolation and physico-chemical properties of a high molecular weight subfragment-2 of myosin.

Authors: K Sutoh; K Sutoh; T Karr; W F Harrington
Journal: J Mol Biol Date: 1978-11-25 Impact factor: 5.469

9. Movement of myosin fragments in vitro: domains involved in force production.

Authors: T R Hynes; S M Block; B T White; J A Spudich
Journal: Cell Date: 1987-03-27 Impact factor: 41.582

10. Local melting in the subfragment-2 region of myosin in activated muscle and its correlation with contractile force.

Authors: H Ueno; W F Harrington
Journal: J Mol Biol Date: 1986-07-05 Impact factor: 5.469

11 in total

1. Contraction characteristics and ATPase activity of skeletal muscle fibers in the presence of antibody to myosin subfragment 2.

Authors: H Sugi; T Kobayashi; T Gross; K Noguchi; T Karr; W F Harrington
Journal: Proc Natl Acad Sci U S A Date: 1992-07-01 Impact factor: 11.205

Suppression of contractile force in muscle fibers by antibody to myosin subfragment 2.

Review 1. Structure of muscle filaments from immunohistochemical and ultrastructural studies.

2. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.

Review 3. Crossbridge behaviour during muscle contraction.

4. On the origin of the contractile force in skeletal muscle.

Review 5. The mechanism of muscular contraction.

6. Proposed mechanism of force generation in striated muscle.

7. Tonicity effects on intact single muscle fibers: relation between force and cell volume.

8. Isolation and physico-chemical properties of a high molecular weight subfragment-2 of myosin.

9. Movement of myosin fragments in vitro: domains involved in force production.

10. Local melting in the subfragment-2 region of myosin in activated muscle and its correlation with contractile force.

1. Contraction characteristics and ATPase activity of skeletal muscle fibers in the presence of antibody to myosin subfragment 2.

2. Contraction of myofibrils in the presence of antibodies to myosin subfragment 2.

3. Single-molecule measurement of the stiffness of the rigor myosin head.

4. Modification of myofibrils by fluorophore-induced photo-oxidation.

5. Alternative S2 hinge regions of the myosin rod affect myofibrillar structure and myosin kinetics.

6. Structural and phylogenetic analysis of the chicken ventricular myosin heavy chain rod.

7. Dynamic electron microscopy of ATP-induced myosin head movement in living muscle thick filaments.

8. Influence of the cardiac myosin hinge region on contractile activity.

9. Large-scale models reveal the two-component mechanics of striated muscle.

10. Evidence that the stalk of Drosophila kinesin heavy chain is an alpha-helical coiled coil.