Mauro Manconi1, Francesco Fanfulla2, Raffaele Ferri2, Silvia Miano2, Josè Haba-Rubio2, Raphael Heinzer2, Thomas Horvath2, Paola Proserpio2, Peter Young2, Giorgio Moschovitis2, Andrea Seiler2, Carlo Cereda2, Lino Nobili2, Roland Wiest2, Sebastian R Ott2, Claudio L Bassetti1. 1. From the Sleep and Epilepsy Center (M.M., F.F., S.M., C.C.,), Neurocenter of Southern Switzerland, Civic Hospital of Lugano; Neurology Department Inselspital (M.M., T.H., A.S., C.L.B.), Bern University Hospital, Switzerland; Sleep Medicine Unit (F.F.), Istituti Clinici Scientifici Maugeri, IRCCS, Scientific Institute of Pavia; Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy; Center for Investigation and Research in Sleep (J.H.-R., R.H.), Lausanne University Hospital, Switzerland; C. Munari Center of Epilepsy Surgery (P.P., L.N.), Niguarda Hospital, Milan, Italy; Klinik für Schlafmedizin und Neuromuskuläre Erkrankungen (P.Y.), Universitätsklinikum Münster, Germany; Department of Cardiology (G.M.), Regional Hospital of Lugano, Switzerland; Department of Neuroscience (L.N.), University of Genoa, Italy; University Institute of Diagnostic and Interventional Neuroradiology (R.W.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and Department of Pulmonary Medicine and University of Bern (S.R.O.), Inselspital, University Hospital, Bern, Switzerland. mauro.manconi@eoc.ch claudio.bassetti@insel.ch. 2. From the Sleep and Epilepsy Center (M.M., F.F., S.M., C.C.,), Neurocenter of Southern Switzerland, Civic Hospital of Lugano; Neurology Department Inselspital (M.M., T.H., A.S., C.L.B.), Bern University Hospital, Switzerland; Sleep Medicine Unit (F.F.), Istituti Clinici Scientifici Maugeri, IRCCS, Scientific Institute of Pavia; Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy; Center for Investigation and Research in Sleep (J.H.-R., R.H.), Lausanne University Hospital, Switzerland; C. Munari Center of Epilepsy Surgery (P.P., L.N.), Niguarda Hospital, Milan, Italy; Klinik für Schlafmedizin und Neuromuskuläre Erkrankungen (P.Y.), Universitätsklinikum Münster, Germany; Department of Cardiology (G.M.), Regional Hospital of Lugano, Switzerland; Department of Neuroscience (L.N.), University of Genoa, Italy; University Institute of Diagnostic and Interventional Neuroradiology (R.W.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and Department of Pulmonary Medicine and University of Bern (S.R.O.), Inselspital, University Hospital, Bern, Switzerland.
Abstract
OBJECTIVE: To define the prevalence, time course, and associated factors of periodic limb movements during sleep (PLMS) in patients with ischemic stroke or TIA. METHODS: Patients enrolled in the prospective Sleep-Disordered Breathing in Transient Ischemia Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy (SAS-CARE) study underwent a double polysomnographic investigation in the acute and chronic phases after stroke/TIA, together with a MRI brain scan and a 24-hour blood pressure evaluation. The prevalence of PLMS in patients was compared with that in a matched sample of randomly selected healthy controls from the HypnoLaus cohort. One hundred sixty-nine recordings were performed in the acute phase and 191 after 3 months (210 recordings were obtained from the same 105 patients in both phases) and were compared to those of 162 controls. RESULTS: The mean number of PLMS per hour and the percentage of participants with a PLMS index >10 and >15 per hour were similar between patients and controls. PLMS remained stable from the acute to the chronic phase after stroke. Factors positively associated with PLMS were age, body mass index, and history of hypertension. Blood pressure over 24 hours and the burden of cerebrovascular damage were similar between the groups with PLMS and without PLMS. CONCLUSIONS: PLMS are equally frequent in patients with stroke/TIA and the general population. The absence of higher blood pressure values and of a greater vascular brain damage found in patients with PLMS compared to those without PLMS might be due to a greater use of antihypertensive medication among patients with PLMS, which corresponds to a higher prevalence of previous diagnosis of hypertension in these patients.
OBJECTIVE: To define the prevalence, time course, and associated factors of periodic limb movements during sleep (PLMS) in patients with ischemic stroke or TIA. METHODS:Patients enrolled in the prospective Sleep-Disordered Breathing in Transient Ischemia Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy (SAS-CARE) study underwent a double polysomnographic investigation in the acute and chronic phases after stroke/TIA, together with a MRI brain scan and a 24-hour blood pressure evaluation. The prevalence of PLMS in patients was compared with that in a matched sample of randomly selected healthy controls from the HypnoLaus cohort. One hundred sixty-nine recordings were performed in the acute phase and 191 after 3 months (210 recordings were obtained from the same 105 patients in both phases) and were compared to those of 162 controls. RESULTS: The mean number of PLMS per hour and the percentage of participants with a PLMS index >10 and >15 per hour were similar between patients and controls. PLMS remained stable from the acute to the chronic phase after stroke. Factors positively associated with PLMS were age, body mass index, and history of hypertension. Blood pressure over 24 hours and the burden of cerebrovascular damage were similar between the groups with PLMS and without PLMS. CONCLUSIONS: PLMS are equally frequent in patients with stroke/TIA and the general population. The absence of higher blood pressure values and of a greater vascular brain damage found in patients with PLMS compared to those without PLMS might be due to a greater use of antihypertensive medication among patients with PLMS, which corresponds to a higher prevalence of previous diagnosis of hypertension in these patients.
Authors: Marco Zucconi; Raffaele Ferri; Richard Allen; Paul Christian Baier; Oliviero Bruni; Sudhansu Chokroverty; Luigi Ferini-Strambi; Stephany Fulda; Diego Garcia-Borreguero; Wayne A Hening; Max Hirshkowitz; Birgit Högl; Magdolna Hornyak; Martin King; Pasquale Montagna; Liborio Parrino; Giuseppe Plazzi; Mario G Terzano Journal: Sleep Med Date: 2006-02-03 Impact factor: 3.492
Authors: G Giannini; S Zanigni; R Melotti; M Gögele; F Provini; M F Facheris; P Cortelli; P P Pramstaller Journal: Eur J Neurol Date: 2013-07-30 Impact factor: 6.089
Authors: Benson Wu; Wassim Tarraf; Douglas M Wallace; Ariana M Stickel; Neil Schneiderman; Susan Redline; Sanjay R Patel; Linda C Gallo; Yasmin Mossavar-Rahmani; Martha L Daviglus; Phyllis C Zee; Gregory A Talavera; Daniela Sotres-Alvarez; Hector M González; Alberto Ramos Journal: PLoS One Date: 2022-04-04 Impact factor: 3.752